Found 3 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
C-X-C chemokine receptor type 3
(Homo sapiens (Human)) | BDBM50349657
(CHEMBL1809017)Show SMILES Fc1ccc(NC(=O)N2C[C@@H](C=C3[C@H]2Cc2c[nH]c4cccc3c24)C(=O)N2CCCC2)cc1 |r,c:11| Show InChI InChI=1S/C26H25FN4O2/c27-18-6-8-19(9-7-18)29-26(33)31-15-17(25(32)30-10-1-2-11-30)12-21-20-4-3-5-22-24(20)16(14-28-22)13-23(21)31/h3-9,12,14,17,23,28H,1-2,10-11,13,15H2,(H,29,33)/t17-,23-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Antagonist activity at human CXCR3 expressed in mouse L1.2 cells assessed as inhibition of ITAC-induced calcium mobilization by FLIPR assay |
Bioorg Med Chem Lett 21: 4745-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.070 BindingDB Entry DOI: 10.7270/Q2VM4CN5 |
More data for this Ligand-Target Pair | |
C-X-C chemokine receptor type 3
(Mus musculus) | BDBM50349657
(CHEMBL1809017)Show SMILES Fc1ccc(NC(=O)N2C[C@@H](C=C3[C@H]2Cc2c[nH]c4cccc3c24)C(=O)N2CCCC2)cc1 |r,c:11| Show InChI InChI=1S/C26H25FN4O2/c27-18-6-8-19(9-7-18)29-26(33)31-15-17(25(32)30-10-1-2-11-30)12-21-20-4-3-5-22-24(20)16(14-28-22)13-23(21)31/h3-9,12,14,17,23,28H,1-2,10-11,13,15H2,(H,29,33)/t17-,23-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Antagonist activity at mouse CXCR3 expressed in mouse L1.2 cells assessed as inhibition of ITAC-induced calcium mobilization by FLIPR assay |
Bioorg Med Chem Lett 21: 4745-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.070 BindingDB Entry DOI: 10.7270/Q2VM4CN5 |
More data for this Ligand-Target Pair | |
C-X-C chemokine receptor type 3
(Homo sapiens (Human)) | BDBM50349657
(CHEMBL1809017)Show SMILES Fc1ccc(NC(=O)N2C[C@@H](C=C3[C@H]2Cc2c[nH]c4cccc3c24)C(=O)N2CCCC2)cc1 |r,c:11| Show InChI InChI=1S/C26H25FN4O2/c27-18-6-8-19(9-7-18)29-26(33)31-15-17(25(32)30-10-1-2-11-30)12-21-20-4-3-5-22-24(20)16(14-28-22)13-23(21)31/h3-9,12,14,17,23,28H,1-2,10-11,13,15H2,(H,29,33)/t17-,23-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Displacement of radiolabeled CXCL11 from human CXCR3 expressed in CHO cells by scintillation proximity assay |
Bioorg Med Chem Lett 21: 4745-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.070 BindingDB Entry DOI: 10.7270/Q2VM4CN5 |
More data for this Ligand-Target Pair | |