Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Mitogen-activated protein kinase kinase kinase 8
(Homo sapiens (Human)) | BDBM21899
(8-bromo-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H-...)Show SMILES Fc1ccc(Nc2c(cnc3c(Br)cc(NCc4cnc[nH]4)cc23)C#N)cc1Cl Show InChI InChI=1S/C20H13BrClFN6/c21-16-4-13(26-9-14-8-25-10-28-14)3-15-19(11(6-24)7-27-20(15)16)29-12-1-2-18(23)17(22)5-12/h1-5,7-8,10,26H,9H2,(H,25,28)(H,27,29) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | 7.2 | 30 |
Wyeth Research
| Assay Description Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati... |
J Med Chem 50: 4728-45 (2007)
Article DOI: 10.1021/jm070436q BindingDB Entry DOI: 10.7270/Q2891441 |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM21899
(8-bromo-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H-...)Show SMILES Fc1ccc(Nc2c(cnc3c(Br)cc(NCc4cnc[nH]4)cc23)C#N)cc1Cl Show InChI InChI=1S/C20H13BrClFN6/c21-16-4-13(26-9-14-8-25-10-28-14)3-15-19(11(6-24)7-27-20(15)16)29-12-1-2-18(23)17(22)5-12/h1-5,7-8,10,26H,9H2,(H,25,28)(H,27,29) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
| Assay Description EGFR kinase activity was assayed using poly(Glu4-Tyr) as a substrate. The phosphorylation of tyrosine residue was detected by an ELISA. IC50 calculat... |
J Med Chem 50: 4728-45 (2007)
Article DOI: 10.1021/jm070436q BindingDB Entry DOI: 10.7270/Q2891441 |
More data for this Ligand-Target Pair | |