Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 398.4 BDBM392878

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392878 (US10301306, Example 76) Show SMILES Fc1ccc(cc1)-c1c2c(CCNC2=O)n(Cc2ccccn2)c1-c1ccncc1 Show InChI InChI=1S/C24H19FN4O/c25-18-6-4-16(5-7-18)21-22-20(10-14-28-24(22)30)29(15-19-3-1-2-11-27-19)23(21)17-8-12-26-13-9-17/h1-9,11-13H,10,14-15H2,(H,28,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.55E+3	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair