Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 409.4 BDBM50083564

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50083564 (CHEMBL3422892) Show SMILES Fc1ccc(cc1)C(=O)N1CCc2c(C1)sc(NCc1cccc(F)c1)c2C#N Show InChI InChI=1S/C22H17F2N3OS/c23-16-6-4-15(5-7-16)22(28)27-9-8-18-19(11-25)21(29-20(18)13-27)26-12-14-2-1-3-17(24)10-14/h1-7,10,26H,8-9,12-13H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.38E+3	n/a	n/a	n/a	n/a	n/a	n/a
Korea Institute of Science and Technology Curated by ChEMBL					Assay Description Antagonist activity at human mGluR1 expressed in human Chem-3 cells assessed as inhibition of L-glutamate-induced calcium release by calcium-5 reagen...				Eur J Med Chem 97: 245-58 (2015) Article DOI: 10.1016/j.ejmech.2015.04.060 BindingDB Entry DOI: 10.7270/Q2FJ2JGT
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