Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Proline-rich AKT1 substrate 1
(Homo sapiens (Human)) | BDBM386052
(4-(4-(2-(azetidin-1-yl)-1-(3-chloro-4-fluorophenyl...)Show SMILES Fc1ccc(cc1Cl)C(CN1CCC1)N1CCN(CC1)c1ncnc2NCC(=O)Nc12 Show InChI InChI=1S/C21H25ClFN7O/c22-15-10-14(2-3-16(15)23)17(12-28-4-1-5-28)29-6-8-30(9-7-29)21-19-20(25-13-26-21)24-11-18(31)27-19/h2-3,10,13,17H,1,4-9,11-12H2,(H,27,31)(H,24,25,26) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin at Madison
| Assay Description A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu... |
J Med Chem 51: 7243-52 (2008)
BindingDB Entry DOI: 10.7270/Q26M394B |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase beta-1 [T412E]
(Homo sapiens (Human)) | BDBM386052
(4-(4-(2-(azetidin-1-yl)-1-(3-chloro-4-fluorophenyl...)Show SMILES Fc1ccc(cc1Cl)C(CN1CCC1)N1CCN(CC1)c1ncnc2NCC(=O)Nc12 Show InChI InChI=1S/C21H25ClFN7O/c22-15-10-14(2-3-16(15)23)17(12-28-4-1-5-28)29-6-8-30(9-7-29)21-19-20(25-13-26-21)24-11-18(31)27-19/h2-3,10,13,17H,1,4-9,11-12H2,(H,27,31)(H,24,25,26) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin at Madison
| Assay Description P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com... |
J Med Chem 51: 7243-52 (2008)
BindingDB Entry DOI: 10.7270/Q26M394B |
More data for this Ligand-Target Pair | |