Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Proline-rich AKT1 substrate 1
(Homo sapiens (Human)) | BDBM386049
(4-(4-(1-(3,4-difluorophenyl)-2-(pyrrolidin-1-yl)et...)Show SMILES Fc1ccc(cc1F)C(CN1CCCC1)N1CCN(CC1)c1ncnc2NCC(=O)Nc12 Show InChI InChI=1S/C22H27F2N7O/c23-16-4-3-15(11-17(16)24)18(13-29-5-1-2-6-29)30-7-9-31(10-8-30)22-20-21(26-14-27-22)25-12-19(32)28-20/h3-4,11,14,18H,1-2,5-10,12-13H2,(H,28,32)(H,25,26,27) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin at Madison
| Assay Description A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu... |
J Med Chem 51: 7243-52 (2008)
BindingDB Entry DOI: 10.7270/Q26M394B |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase beta-1 [T412E]
(Homo sapiens (Human)) | BDBM386049
(4-(4-(1-(3,4-difluorophenyl)-2-(pyrrolidin-1-yl)et...)Show SMILES Fc1ccc(cc1F)C(CN1CCCC1)N1CCN(CC1)c1ncnc2NCC(=O)Nc12 Show InChI InChI=1S/C22H27F2N7O/c23-16-4-3-15(11-17(16)24)18(13-29-5-1-2-6-29)30-7-9-31(10-8-30)22-20-21(26-14-27-22)25-12-19(32)28-20/h3-4,11,14,18H,1-2,5-10,12-13H2,(H,28,32)(H,25,26,27) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin at Madison
| Assay Description P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com... |
J Med Chem 51: 7243-52 (2008)
BindingDB Entry DOI: 10.7270/Q26M394B |
More data for this Ligand-Target Pair | |