Found 3 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50545278
(CHEMBL2441563)Show SMILES Fc1cccc(COc2ccc(Nc3ncnc4cc5OCCN(C(=O)\C=C\CN6CCOCC6)c5cc34)cc2Cl)c1 Show InChI InChI=1S/C31H29ClFN5O4/c32-25-16-23(6-7-28(25)42-19-21-3-1-4-22(33)15-21)36-31-24-17-27-29(18-26(24)34-20-35-31)41-14-11-38(27)30(39)5-2-8-37-9-12-40-13-10-37/h1-7,15-18,20H,8-14,19H2,(H,34,35,36)/b5-2+ | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Jiangsu Aosaikang Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description Inhibition of EGFR (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured after 40 ... |
Bioorg Med Chem Lett 30: (2020)
Article DOI: 10.1016/j.bmcl.2020.127045 BindingDB Entry DOI: 10.7270/Q2G44TV0 |
More data for this Ligand-Target Pair | |
Receptor tyrosine-protein kinase erbB-2
(Homo sapiens (Human)) | BDBM50545278
(CHEMBL2441563)Show SMILES Fc1cccc(COc2ccc(Nc3ncnc4cc5OCCN(C(=O)\C=C\CN6CCOCC6)c5cc34)cc2Cl)c1 Show InChI InChI=1S/C31H29ClFN5O4/c32-25-16-23(6-7-28(25)42-19-21-3-1-4-22(33)15-21)36-31-24-17-27-29(18-26(24)34-20-35-31)41-14-11-38(27)30(39)5-2-8-37-9-12-40-13-10-37/h1-7,15-18,20H,8-14,19H2,(H,34,35,36)/b5-2+ | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Jiangsu Aosaikang Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description Inhibition of HER2 (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured after 40 ... |
Bioorg Med Chem Lett 30: (2020)
Article DOI: 10.1016/j.bmcl.2020.127045 BindingDB Entry DOI: 10.7270/Q2G44TV0 |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50545278
(CHEMBL2441563)Show SMILES Fc1cccc(COc2ccc(Nc3ncnc4cc5OCCN(C(=O)\C=C\CN6CCOCC6)c5cc34)cc2Cl)c1 Show InChI InChI=1S/C31H29ClFN5O4/c32-25-16-23(6-7-28(25)42-19-21-3-1-4-22(33)15-21)36-31-24-17-27-29(18-26(24)34-20-35-31)41-14-11-38(27)30(39)5-2-8-37-9-12-40-13-10-37/h1-7,15-18,20H,8-14,19H2,(H,34,35,36)/b5-2+ | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Jiangsu Aosaikang Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description Inhibition of EGFR in human KB cells assessed as reduction in EGF-stimulated EGFR phosphorylation preincubated for 1 hr followed by EGF stimulation a... |
Bioorg Med Chem Lett 30: (2020)
Article DOI: 10.1016/j.bmcl.2020.127045 BindingDB Entry DOI: 10.7270/Q2G44TV0 |
More data for this Ligand-Target Pair | |