Found 4 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Metabotropic glutamate receptor 5
(Homo sapiens (Human)) | BDBM136035
(US8853203, 88b | US9650377, Example 88b)Show SMILES Fc1nccnc1-c1cccc2C3=CC(=NCC(=O)N3CCc12)n1cnc(n1)C1CC1 |c:15,t:13| Show InChI InChI=1S/C22H18FN7O/c23-21-20(24-7-8-25-21)16-3-1-2-15-14(16)6-9-29-17(15)10-18(26-11-19(29)31)30-12-27-22(28-30)13-4-5-13/h1-3,7-8,10,12-13H,4-6,9,11H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce... |
US Patent US9650377 (2017)
BindingDB Entry DOI: 10.7270/Q2G73GT2 |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Homo sapiens (Human)) | BDBM136035
(US8853203, 88b | US9650377, Example 88b)Show SMILES Fc1nccnc1-c1cccc2C3=CC(=NCC(=O)N3CCc12)n1cnc(n1)C1CC1 |c:15,t:13| Show InChI InChI=1S/C22H18FN7O/c23-21-20(24-7-8-25-21)16-3-1-2-15-14(16)6-9-29-17(15)10-18(26-11-19(29)31)30-12-27-22(28-30)13-4-5-13/h1-3,7-8,10,12-13H,4-6,9,11H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description Activity of compounds of the present invention was examined by determination to what extent the glutamate-induced elevation of the intracellular calc... |
US Patent US8853203 (2014)
BindingDB Entry DOI: 10.7270/Q2MP520T |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(Homo sapiens (Human)) | BDBM136035
(US8853203, 88b | US9650377, Example 88b)Show SMILES Fc1nccnc1-c1cccc2C3=CC(=NCC(=O)N3CCc12)n1cnc(n1)C1CC1 |c:15,t:13| Show InChI InChI=1S/C22H18FN7O/c23-21-20(24-7-8-25-21)16-3-1-2-15-14(16)6-9-29-17(15)10-18(26-11-19(29)31)30-12-27-22(28-30)13-4-5-13/h1-3,7-8,10,12-13H,4-6,9,11H2 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description Activity of compounds of the present invention was examined by determination to what extent the glutamate-induced elevation of the intracellular calc... |
US Patent US9650377 (2017)
BindingDB Entry DOI: 10.7270/Q2G73GT2 |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(Homo sapiens (Human)) | BDBM136035
(US8853203, 88b | US9650377, Example 88b)Show SMILES Fc1nccnc1-c1cccc2C3=CC(=NCC(=O)N3CCc12)n1cnc(n1)C1CC1 |c:15,t:13| Show InChI InChI=1S/C22H18FN7O/c23-21-20(24-7-8-25-21)16-3-1-2-15-14(16)6-9-29-17(15)10-18(26-11-19(29)31)30-12-27-22(28-30)13-4-5-13/h1-3,7-8,10,12-13H,4-6,9,11H2 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description Activity of compounds of the present invention was examined by determination to what extent the glutamate-induced elevation of the intracellular calc... |
US Patent US8853203 (2014)
BindingDB Entry DOI: 10.7270/Q2MP520T |
More data for this Ligand-Target Pair | |