Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50312939
((S)-4-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc(cc1)C(N)=O)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C20H19F3N4OS/c21-20(22,23)15-7-1-12(2-8-15)9-16(24)10-26-19-27-11-17(29-19)13-3-5-14(6-4-13)18(25)28/h1-8,11,16H,9-10,24H2,(H2,25,28)(H,26,27)/t16-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISA |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067 BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50312939
((S)-4-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)pro...)Show SMILES N[C@H](CNc1ncc(s1)-c1ccc(cc1)C(N)=O)Cc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C20H19F3N4OS/c21-20(22,23)15-7-1-12(2-8-15)9-16(24)10-26-19-27-11-17(29-19)13-3-5-14(6-4-13)18(25)28/h1-8,11,16H,9-10,24H2,(H2,25,28)(H,26,27)/t16-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of CDK2 |
Bioorg Med Chem Lett 20: 1559-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.067 BindingDB Entry DOI: 10.7270/Q20C4VWX |
More data for this Ligand-Target Pair | |