Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 395.8 BDBM50327797

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 4 hits in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50327797 ((R)-2-amino-3-(4-chlorophenyl)-1-(4-(quinazolin-4-...) Show SMILES N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(CC1)c1ncnc2ccccc12 |r| Show InChI InChI=1S/C21H22ClN5O/c22-16-7-5-15(6-8-16)13-18(23)21(28)27-11-9-26(10-12-27)20-17-3-1-2-4-19(17)24-14-25-20/h1-8,14,18H,9-13,23H2/t18-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc Curated by ChEMBL					Assay Description Inhibition of AKT1 by IMAP assay				Bioorg Med Chem Lett 20: 5607-12 (2010) Article DOI: 10.1016/j.bmcl.2010.08.053 BindingDB Entry DOI: 10.7270/Q2M908XQ
					More data for this Ligand-Target Pair
RAC-beta serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50327797 ((R)-2-amino-3-(4-chlorophenyl)-1-(4-(quinazolin-4-...) Show SMILES N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(CC1)c1ncnc2ccccc12 |r| Show InChI InChI=1S/C21H22ClN5O/c22-16-7-5-15(6-8-16)13-18(23)21(28)27-11-9-26(10-12-27)20-17-3-1-2-4-19(17)24-14-25-20/h1-8,14,18H,9-13,23H2/t18-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	118	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc Curated by ChEMBL					Assay Description Inhibition of AKT2 by IMAP assay				Bioorg Med Chem Lett 20: 5607-12 (2010) Article DOI: 10.1016/j.bmcl.2010.08.053 BindingDB Entry DOI: 10.7270/Q2M908XQ
					More data for this Ligand-Target Pair
RAC-gamma serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50327797 ((R)-2-amino-3-(4-chlorophenyl)-1-(4-(quinazolin-4-...) Show SMILES N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(CC1)c1ncnc2ccccc12 |r| Show InChI InChI=1S/C21H22ClN5O/c22-16-7-5-15(6-8-16)13-18(23)21(28)27-11-9-26(10-12-27)20-17-3-1-2-4-19(17)24-14-25-20/h1-8,14,18H,9-13,23H2/t18-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	179	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc Curated by ChEMBL					Assay Description Inhibition of AKT3 by IMAP assay				Bioorg Med Chem Lett 20: 5607-12 (2010) Article DOI: 10.1016/j.bmcl.2010.08.053 BindingDB Entry DOI: 10.7270/Q2M908XQ
					More data for this Ligand-Target Pair
Proline-rich AKT1 substrate 1 (Homo sapiens (Human))	BDBM50327797 ((R)-2-amino-3-(4-chlorophenyl)-1-(4-(quinazolin-4-...) Show SMILES N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(CC1)c1ncnc2ccccc12 |r| Show InChI InChI=1S/C21H22ClN5O/c22-16-7-5-15(6-8-16)13-18(23)21(28)27-11-9-26(10-12-27)20-17-3-1-2-4-19(17)24-14-25-20/h1-8,14,18H,9-13,23H2/t18-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc Curated by ChEMBL					Assay Description Inhibition of PRAS40 phosphorylation at Thr246 in human LNCaP cells after 1.5 hrs				Bioorg Med Chem Lett 20: 5607-12 (2010) Article DOI: 10.1016/j.bmcl.2010.08.053 BindingDB Entry DOI: 10.7270/Q2M908XQ
					More data for this Ligand-Target Pair