Found 4 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Neuropeptide Y receptor type 1
(Homo sapiens (Human)) | BDBM50090271
(2-[2-(4-Chloro-phenyl)-2-phenyl-acetylamino]-5-gua...)Show SMILES NC(=N)NCCCC(NC(=O)C(c1ccccc1)c1ccc(Cl)cc1)C(=O)N[C@H]1CCc2ccccc12 Show InChI InChI=1S/C29H32ClN5O2/c30-22-15-12-21(13-16-22)26(20-8-2-1-3-9-20)28(37)35-25(11-6-18-33-29(31)32)27(36)34-24-17-14-19-7-4-5-10-23(19)24/h1-5,7-10,12-13,15-16,24-26H,6,11,14,17-18H2,(H,34,36)(H,35,37)(H4,31,32,33)/t24-,25?,26?/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Regensburg
Curated by ChEMBL
| Assay Description
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentr... |
Bioorg Med Chem Lett 10: 1597-600 (2000)
BindingDB Entry DOI: 10.7270/Q2HD7TWN |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 1
(Homo sapiens (Human)) | BDBM50090271
(2-[2-(4-Chloro-phenyl)-2-phenyl-acetylamino]-5-gua...)Show SMILES NC(=N)NCCCC(NC(=O)C(c1ccccc1)c1ccc(Cl)cc1)C(=O)N[C@H]1CCc2ccccc12 Show InChI InChI=1S/C29H32ClN5O2/c30-22-15-12-21(13-16-22)26(20-8-2-1-3-9-20)28(37)35-25(11-6-18-33-29(31)32)27(36)34-24-17-14-19-7-4-5-10-23(19)24/h1-5,7-10,12-13,15-16,24-26H,6,11,14,17-18H2,(H,34,36)(H,35,37)(H4,31,32,33)/t24-,25?,26?/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 5.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Regensburg
Curated by ChEMBL
| Assay Description
Inhibition of binding of [3H]-propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cells |
Bioorg Med Chem Lett 10: 1597-600 (2000)
BindingDB Entry DOI: 10.7270/Q2HD7TWN |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50090271
(2-[2-(4-Chloro-phenyl)-2-phenyl-acetylamino]-5-gua...)Show SMILES NC(=N)NCCCC(NC(=O)C(c1ccccc1)c1ccc(Cl)cc1)C(=O)N[C@H]1CCc2ccccc12 Show InChI InChI=1S/C29H32ClN5O2/c30-22-15-12-21(13-16-22)26(20-8-2-1-3-9-20)28(37)35-25(11-6-18-33-29(31)32)27(36)34-24-17-14-19-7-4-5-10-23(19)24/h1-5,7-10,12-13,15-16,24-26H,6,11,14,17-18H2,(H,34,36)(H,35,37)(H4,31,32,33)/t24-,25?,26?/m0/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.19E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Regensburg
Curated by ChEMBL
| Assay Description
Inhibition of binding of [3H]-propionyl-NPY (1 nM) to Neuropeptide Y receptor type 5 in HEC-1-B cells |
Bioorg Med Chem Lett 10: 1597-600 (2000)
BindingDB Entry DOI: 10.7270/Q2HD7TWN |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM50090271
(2-[2-(4-Chloro-phenyl)-2-phenyl-acetylamino]-5-gua...)Show SMILES NC(=N)NCCCC(NC(=O)C(c1ccccc1)c1ccc(Cl)cc1)C(=O)N[C@H]1CCc2ccccc12 Show InChI InChI=1S/C29H32ClN5O2/c30-22-15-12-21(13-16-22)26(20-8-2-1-3-9-20)28(37)35-25(11-6-18-33-29(31)32)27(36)34-24-17-14-19-7-4-5-10-23(19)24/h1-5,7-10,12-13,15-16,24-26H,6,11,14,17-18H2,(H,34,36)(H,35,37)(H4,31,32,33)/t24-,25?,26?/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 5.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Regensburg
Curated by ChEMBL
| Assay Description
Inhibition of binding of [3H]-propionyl-NPY (1 nM) to Neuropeptide Y receptor type 2 in SMS-KAN cell membranes |
Bioorg Med Chem Lett 10: 1597-600 (2000)
BindingDB Entry DOI: 10.7270/Q2HD7TWN |
More data for this
Ligand-Target Pair | |