Found 4 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Opioid growth factor receptor-like protein 1
(Homo sapiens (Human)) | BDBM133859
(US8846929, 26)Show SMILES NC(=N)NCCNc1nc2ccccc2n(C2CCN(CC2)C2CCCCCCC2)c1=O Show InChI InChI=1S/C24H37N7O/c25-24(26)28-15-14-27-22-23(32)31(21-11-7-6-10-20(21)29-22)19-12-16-30(17-13-19)18-8-4-2-1-3-5-9-18/h6-7,10-11,18-19H,1-5,8-9,12-17H2,(H,27,29)(H4,25,26,28) | KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| 7.10 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Purdue Pharma L.P.; Shionogi & Co., Ltd.
US Patent
| Assay Description Radioligand binding assays (screening and dose-displacement) used 0.1nM [3H]-nociceptin (NEN; 87.7 Cl/nimole) with 10-20 ug membrane protein in a fin... |
US Patent US8846929 (2014)
BindingDB Entry DOI: 10.7270/Q2G44P04 |
More data for this Ligand-Target Pair | |
Kappa-type opioid receptor
(Homo sapiens (Human)) | BDBM133859
(US8846929, 26)Show SMILES NC(=N)NCCNc1nc2ccccc2n(C2CCN(CC2)C2CCCCCCC2)c1=O Show InChI InChI=1S/C24H37N7O/c25-24(26)28-15-14-27-22-23(32)31(21-11-7-6-10-20(21)29-22)19-12-16-30(17-13-19)18-8-4-2-1-3-5-9-18/h6-7,10-11,18-19H,1-5,8-9,12-17H2,(H,27,29)(H4,25,26,28) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| 191 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Purdue Pharma L.P.; Shionogi & Co., Ltd.
US Patent
| Assay Description Radioligand dose displacement assays used 0.4-0.8nM [3H]-U69,593 (NEN; 40 Ci/mmole) with 10-20 ug membrane protein (recombinant kappa opioid receptor... |
US Patent US8846929 (2014)
BindingDB Entry DOI: 10.7270/Q2G44P04 |
More data for this Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM133859
(US8846929, 26)Show SMILES NC(=N)NCCNc1nc2ccccc2n(C2CCN(CC2)C2CCCCCCC2)c1=O Show InChI InChI=1S/C24H37N7O/c25-24(26)28-15-14-27-22-23(32)31(21-11-7-6-10-20(21)29-22)19-12-16-30(17-13-19)18-8-4-2-1-3-5-9-18/h6-7,10-11,18-19H,1-5,8-9,12-17H2,(H,27,29)(H4,25,26,28) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| 629 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Purdue Pharma L.P.; Shionogi & Co., Ltd.
US Patent
| Assay Description Radioligand dose-displacement binding assays for u-opioid receptors used 0.2nM[3H]-diprenorphine (NEN, Boston, Mass.), with 5-20mg membrane protein/w... |
US Patent US8846929 (2014)
BindingDB Entry DOI: 10.7270/Q2G44P04 |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor
(Homo sapiens (Human)) | BDBM133859
(US8846929, 26)Show SMILES NC(=N)NCCNc1nc2ccccc2n(C2CCN(CC2)C2CCCCCCC2)c1=O Show InChI InChI=1S/C24H37N7O/c25-24(26)28-15-14-27-22-23(32)31(21-11-7-6-10-20(21)29-22)19-12-16-30(17-13-19)18-8-4-2-1-3-5-9-18/h6-7,10-11,18-19H,1-5,8-9,12-17H2,(H,27,29)(H4,25,26,28) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| 3.59E+4 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Purdue Pharma L.P.; Shionogi & Co., Ltd.
US Patent
| Assay Description Radioligand dose-displacement assays used 0.2nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20ug membrane protein (recombinant delta opioid recepto... |
US Patent US8846929 (2014)
BindingDB Entry DOI: 10.7270/Q2G44P04 |
More data for this Ligand-Target Pair | |