Found 4 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Calcium-dependent protein kinase 1
(Cryptosporidium parvum) | BDBM286283
(US9518026, Example 76 | US9956214, Compound 1658)Show SMILES NC(=O)c1c(N)n(nc1-c1cnc2cc(OC3CCC3)ccc2c1)C1CCCC1 Show InChI InChI=1S/C22H25N5O2/c23-21-19(22(24)28)20(26-27(21)15-4-1-2-5-15)14-10-13-8-9-17(11-18(13)25-12-14)29-16-6-3-7-16/h8-12,15-16H,1-7,23H2,(H2,24,28) | UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim (Canada) Ltd.
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
Bioorg Med Chem Lett 19: 1199-205 (2009)
BindingDB Entry DOI: 10.7270/Q23J3G91 |
More data for this Ligand-Target Pair | |
Uncharacterized protein
(Cryptosporidium parvum) | BDBM286283
(US9518026, Example 76 | US9956214, Compound 1658)Show SMILES NC(=O)c1c(N)n(nc1-c1cnc2cc(OC3CCC3)ccc2c1)C1CCCC1 Show InChI InChI=1S/C22H25N5O2/c23-21-19(22(24)28)20(26-27(21)15-4-1-2-5-15)14-10-13-8-9-17(11-18(13)25-12-14)29-16-6-3-7-16/h8-12,15-16H,1-7,23H2,(H2,24,28) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center For Commercialization
US Patent
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US9518026 (2016)
BindingDB Entry DOI: 10.7270/Q2BV7JN4 |
More data for this Ligand-Target Pair | |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM286283
(US9518026, Example 76 | US9956214, Compound 1658)Show SMILES NC(=O)c1c(N)n(nc1-c1cnc2cc(OC3CCC3)ccc2c1)C1CCCC1 Show InChI InChI=1S/C22H25N5O2/c23-21-19(22(24)28)20(26-27(21)15-4-1-2-5-15)14-10-13-8-9-17(11-18(13)25-12-14)29-16-6-3-7-16/h8-12,15-16H,1-7,23H2,(H2,24,28) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim (Canada) Ltd.
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
Bioorg Med Chem Lett 19: 1199-205 (2009)
BindingDB Entry DOI: 10.7270/Q23J3G91 |
More data for this Ligand-Target Pair | |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM286283
(US9518026, Example 76 | US9956214, Compound 1658)Show SMILES NC(=O)c1c(N)n(nc1-c1cnc2cc(OC3CCC3)ccc2c1)C1CCCC1 Show InChI InChI=1S/C22H25N5O2/c23-21-19(22(24)28)20(26-27(21)15-4-1-2-5-15)14-10-13-8-9-17(11-18(13)25-12-14)29-16-6-3-7-16/h8-12,15-16H,1-7,23H2,(H2,24,28) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center For Commercialization
US Patent
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US9518026 (2016)
BindingDB Entry DOI: 10.7270/Q2BV7JN4 |
More data for this Ligand-Target Pair | |