Found 4 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50512420
(CHEMBL4469681)Show SMILES NC(=O)c1c(N)nn2cc(cnc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C17H16F2N6O/c18-9-3-4-12(19)11(6-9)13-2-1-5-24(13)10-7-22-17-14(16(21)26)15(20)23-25(17)8-10/h3-4,6-8,13H,1-2,5H2,(H2,20,23)(H2,21,26)/t13-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of N- terminal GST-tagged human TRKA cytoplasmic domain (436 to 790 end residues) using TK peptide as substrate after 60 mins by HTRF assa... |
Eur J Med Chem 175: 129-148 (2019)
Article DOI: 10.1016/j.ejmech.2019.04.053
BindingDB Entry DOI: 10.7270/Q25M691T |
More data for this
Ligand-Target Pair | |
NT-3 growth factor receptor
(Homo sapiens (Human)) | BDBM50512420
(CHEMBL4469681)Show SMILES NC(=O)c1c(N)nn2cc(cnc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C17H16F2N6O/c18-9-3-4-12(19)11(6-9)13-2-1-5-24(13)10-7-22-17-14(16(21)26)15(20)23-25(17)8-10/h3-4,6-8,13H,1-2,5H2,(H2,20,23)(H2,21,26)/t13-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of N- terminal GST-tagged human TRKC catalytic domain (456 to 825 end residues) expressed in baculovirus expression system using TK peptid... |
Eur J Med Chem 175: 129-148 (2019)
Article DOI: 10.1016/j.ejmech.2019.04.053
BindingDB Entry DOI: 10.7270/Q25M691T |
More data for this
Ligand-Target Pair | |
BDNF/NT-3 growth factors receptor
(Homo sapiens (Human)) | BDBM50512420
(CHEMBL4469681)Show SMILES NC(=O)c1c(N)nn2cc(cnc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C17H16F2N6O/c18-9-3-4-12(19)11(6-9)13-2-1-5-24(13)10-7-22-17-14(16(21)26)15(20)23-25(17)8-10/h3-4,6-8,13H,1-2,5H2,(H2,20,23)(H2,21,26)/t13-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of N- terminal GST-tagged human TRKB cytoplasmic domain (456 to 822 end residues) expressed in baculovirus expression system using TK pept... |
Eur J Med Chem 175: 129-148 (2019)
Article DOI: 10.1016/j.ejmech.2019.04.053
BindingDB Entry DOI: 10.7270/Q25M691T |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50512420
(CHEMBL4469681)Show SMILES NC(=O)c1c(N)nn2cc(cnc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C17H16F2N6O/c18-9-3-4-12(19)11(6-9)13-2-1-5-24(13)10-7-22-17-14(16(21)26)15(20)23-25(17)8-10/h3-4,6-8,13H,1-2,5H2,(H2,20,23)(H2,21,26)/t13-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal His-tagged human JAK2 catalytic domain (826 to 1132 end residues) expressed in baculovirus expression system using TK peptid... |
Eur J Med Chem 175: 129-148 (2019)
Article DOI: 10.1016/j.ejmech.2019.04.053
BindingDB Entry DOI: 10.7270/Q25M691T |
More data for this
Ligand-Target Pair | |