Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Branched-chain-amino-acid aminotransferase, mitochondrial
(Homo sapiens (Human)) | BDBM50173918
(CHEMBL3809916)Show SMILES NC(=O)c1ccc2n([C@@H]3CCC[C@@H](C3)NC(=O)c3ccc(s3)C#N)c(nc2c1)-c1ccccn1 |r| Show InChI InChI=1S/C25H22N6O2S/c26-14-18-8-10-22(34-18)25(33)29-16-4-3-5-17(13-16)31-21-9-7-15(23(27)32)12-20(21)30-24(31)19-6-1-2-11-28-19/h1-2,6-12,16-17H,3-5,13H2,(H2,27,32)(H,29,33)/t16-,17+/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 251 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of human BCATm (28 to 392 residues) using L-Leucine and alpha-ketogluterate as substrate assessed as L-glutamate production after 10 mins ... |
ACS Med Chem Lett 7: 379-84 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00389 BindingDB Entry DOI: 10.7270/Q2W097V6 |
More data for this Ligand-Target Pair | |
Branched-chain-amino-acid aminotransferase, mitochondrial
(Homo sapiens (Human)) | BDBM50173918
(CHEMBL3809916)Show SMILES NC(=O)c1ccc2n([C@@H]3CCC[C@@H](C3)NC(=O)c3ccc(s3)C#N)c(nc2c1)-c1ccccn1 |r| Show InChI InChI=1S/C25H22N6O2S/c26-14-18-8-10-22(34-18)25(33)29-16-4-3-5-17(13-16)31-21-9-7-15(23(27)32)12-20(21)30-24(31)19-6-1-2-11-28-19/h1-2,6-12,16-17H,3-5,13H2,(H2,27,32)(H,29,33)/t16-,17+/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.26E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of BCATm in differentiated primary human adipocytes using L-Serine and L-Leucine as substrate after overnight incubation by reverse-phase ... |
ACS Med Chem Lett 7: 379-84 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00389 BindingDB Entry DOI: 10.7270/Q2W097V6 |
More data for this Ligand-Target Pair | |