Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Acyl-CoA desaturase 1
(Rattus norvegicus (Rat)) | BDBM50312691
(5-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl)-1...)Show SMILES NC(=O)c1nnc([nH]1)N1CCC(CC1)Oc1ccccc1C(F)(F)F Show InChI InChI=1S/C15H16F3N5O2/c16-15(17,18)10-3-1-2-4-11(10)25-9-5-7-23(8-6-9)14-20-13(12(19)24)21-22-14/h1-4,9H,5-8H2,(H2,19,24)(H,20,21,22) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 127 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description Inhibition of SCD1 in Wistar rat liver microsome assessed as [3H]stearoyl-CoA to [3H]oleoyl-CoA conversion pretreated 1 hr before [3H]stearoyl-CoA ad... |
Bioorg Med Chem Lett 20: 1593-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.083 BindingDB Entry DOI: 10.7270/Q2DJ5FR0 |
More data for this Ligand-Target Pair | |
Stearoyl-CoA desaturase
(Homo sapiens (Human)) | BDBM50312691
(5-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl)-1...)Show SMILES NC(=O)c1nnc([nH]1)N1CCC(CC1)Oc1ccccc1C(F)(F)F Show InChI InChI=1S/C15H16F3N5O2/c16-15(17,18)10-3-1-2-4-11(10)25-9-5-7-23(8-6-9)14-20-13(12(19)24)21-22-14/h1-4,9H,5-8H2,(H2,19,24)(H,20,21,22) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.82E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description Inhibition of SCD1 in human HepG2 cells assessed as [14C]stearic acid to [14C]oleic acid conversion pretreated 15 mins before [14C]stearic acid addit... |
Bioorg Med Chem Lett 20: 1593-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.083 BindingDB Entry DOI: 10.7270/Q2DJ5FR0 |
More data for this Ligand-Target Pair | |