Found 3 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Amiloride-sensitive sodium channel subunit alpha
(Homo sapiens (Human)) | BDBM50190487
(CHEMBL212531 | N-(3,5-diamino-6-chloropyrazine-2-c...)Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(OC[C@@H](O)CO)cc1 |w:14.15| Show InChI InChI=1S/C19H26ClN7O4/c20-15-17(22)26-16(21)14(25-15)18(30)27-19(23)24-8-2-1-3-11-4-6-13(7-5-11)31-10-12(29)9-28/h4-7,12,28-29H,1-3,8-10H2,(H4,21,22,26)(H3,23,24,27,30)/t12-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Parion Sciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay |
J Med Chem 49: 4098-115 (2006)
Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Homo sapiens (Human)) | BDBM50190462
(CHEMBL212432 | N-(3,5-diamino-6-chloropyrazine-2-c...)Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(OCC(O)CO)cc1 |w:14.15| Show InChI InChI=1S/C19H26ClN7O4/c20-15-17(22)26-16(21)14(25-15)18(30)27-19(23)24-8-2-1-3-11-4-6-13(7-5-11)31-10-12(29)9-28/h4-7,12,28-29H,1-3,8-10H2,(H4,21,22,26)(H3,23,24,27,30) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Parion Sciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay |
J Med Chem 49: 4098-115 (2006)
Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH |
More data for this
Ligand-Target Pair | |
Amiloride-sensitive sodium channel subunit alpha
(Homo sapiens (Human)) | BDBM50190494
(CHEMBL209303 | N-(3,5-diamino-6-chloropyrazine-2-c...)Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(OC[C@H](O)CO)cc1 |w:14.15| Show InChI InChI=1S/C19H26ClN7O4/c20-15-17(22)26-16(21)14(25-15)18(30)27-19(23)24-8-2-1-3-11-4-6-13(7-5-11)31-10-12(29)9-28/h4-7,12,28-29H,1-3,8-10H2,(H4,21,22,26)(H3,23,24,27,30)/t12-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Parion Sciences Inc.
Curated by ChEMBL
| Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay |
J Med Chem 49: 4098-115 (2006)
Article DOI: 10.1021/jm051134w
BindingDB Entry DOI: 10.7270/Q2FT8KNH |
More data for this
Ligand-Target Pair | |