Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 451.9 BDBM50190490

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Amiloride-sensitive sodium channel subunit alpha (Homo sapiens (Human))	BDBM50190490 (CHEMBL212534 | N-(3,5-diamino-6-chloropyrazine-2-c...) Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1cccc(OCC(O)CO)c1 |w:14.15| Show InChI InChI=1S/C19H26ClN7O4/c20-15-17(22)26-16(21)14(25-15)18(30)27-19(23)24-7-2-1-4-11-5-3-6-13(8-11)31-10-12(29)9-28/h3,5-6,8,12,28-29H,1-2,4,7,9-10H2,(H4,21,22,26)(H3,23,24,27,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
Parion Sciences Inc. Curated by ChEMBL					Assay Description Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay				J Med Chem 49: 4098-115 (2006) Article DOI: 10.1021/jm051134w BindingDB Entry DOI: 10.7270/Q2FT8KNH
					More data for this Ligand-Target Pair