Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 363.8 BDBM50190472

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Amiloride-sensitive sodium channel subunit alpha (Homo sapiens (Human))	BDBM50190472 (CHEMBL211793 | N-(3,5-diamino-6-chloropyrazine-2-c...) Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCc1ccc(O)cc1 |w:14.15| Show InChI InChI=1S/C15H18ClN7O2/c16-11-13(18)22-12(17)10(21-11)14(25)23-15(19)20-7-1-2-8-3-5-9(24)6-4-8/h3-6,24H,1-2,7H2,(H4,17,18,22)(H3,19,20,23,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	88	n/a	n/a	n/a	n/a	n/a	n/a
Parion Sciences Inc. Curated by ChEMBL					Assay Description Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay				J Med Chem 49: 4098-115 (2006) Article DOI: 10.1021/jm051134w BindingDB Entry DOI: 10.7270/Q2FT8KNH
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