Found 4 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Beta-secretase 1
(Homo sapiens (Human)) | BDBM171782
(US9085576, 407 | US9611261, Example 407)Show SMILES NC1=N[C@@](C(F)F)([C@H]2C[C@H]2O1)c1cc(NC(=O)c2cnc(cn2)C#CC2CC2)ccc1F |r,t:1| Show InChI InChI=1S/C22H18F3N5O2/c23-16-6-5-12(7-14(16)22(20(24)25)15-8-18(15)32-21(26)30-22)29-19(31)17-10-27-13(9-28-17)4-3-11-1-2-11/h5-7,9-11,15,18,20H,1-2,8H2,(H2,26,30)(H,29,31)/t15-,18+,22+/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 29.6 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic... |
US Patent US9611261 (2017)
BindingDB Entry DOI: 10.7270/Q21J9CW2 |
More data for this Ligand-Target Pair | |
Beta-secretase 1
(Homo sapiens (Human)) | BDBM171782
(US9085576, 407 | US9611261, Example 407)Show SMILES NC1=N[C@@](C(F)F)([C@H]2C[C@H]2O1)c1cc(NC(=O)c2cnc(cn2)C#CC2CC2)ccc1F |r,t:1| Show InChI InChI=1S/C22H18F3N5O2/c23-16-6-5-12(7-14(16)22(20(24)25)15-8-18(15)32-21(26)30-22)29-19(31)17-10-27-13(9-28-17)4-3-11-1-2-11/h5-7,9-11,15,18,20H,1-2,8H2,(H2,26,30)(H,29,31)/t15-,18+,22+/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 29.6 | n/a | n/a | n/a | n/a | 4.2 | n/a |
AMGEN INC.
US Patent
| Assay Description The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic... |
US Patent US9085576 (2015)
BindingDB Entry DOI: 10.7270/Q2CF9NWF |
More data for this Ligand-Target Pair | |
Cathepsin D
(Homo sapiens (Human)) | BDBM171782
(US9085576, 407 | US9611261, Example 407)Show SMILES NC1=N[C@@](C(F)F)([C@H]2C[C@H]2O1)c1cc(NC(=O)c2cnc(cn2)C#CC2CC2)ccc1F |r,t:1| Show InChI InChI=1S/C22H18F3N5O2/c23-16-6-5-12(7-14(16)22(20(24)25)15-8-18(15)32-21(26)30-22)29-19(31)17-10-27-13(9-28-17)4-3-11-1-2-11/h5-7,9-11,15,18,20H,1-2,8H2,(H2,26,30)(H,29,31)/t15-,18+,22+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 1.70E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ... |
US Patent US9611261 (2017)
BindingDB Entry DOI: 10.7270/Q21J9CW2 |
More data for this Ligand-Target Pair | |
Cathepsin D
(Homo sapiens (Human)) | BDBM171782
(US9085576, 407 | US9611261, Example 407)Show SMILES NC1=N[C@@](C(F)F)([C@H]2C[C@H]2O1)c1cc(NC(=O)c2cnc(cn2)C#CC2CC2)ccc1F |r,t:1| Show InChI InChI=1S/C22H18F3N5O2/c23-16-6-5-12(7-14(16)22(20(24)25)15-8-18(15)32-21(26)30-22)29-19(31)17-10-27-13(9-28-17)4-3-11-1-2-11/h5-7,9-11,15,18,20H,1-2,8H2,(H2,26,30)(H,29,31)/t15-,18+,22+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 1.70E+5 | n/a | n/a | n/a | n/a | 3.5 | n/a |
AMGEN INC.
US Patent
| Assay Description Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ... |
US Patent US9085576 (2015)
BindingDB Entry DOI: 10.7270/Q2CF9NWF |
More data for this Ligand-Target Pair | |