Found 3 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Beta-secretase 1
(Homo sapiens (Human)) | BDBM214836
(US9296734, 36)Show SMILES NC1=N[C@@](CF)(C[C@H](O1)C(F)(F)F)c1cc(NC(=O)c2nn(cc2Cl)C(F)F)ccc1F |r,t:1| Show InChI InChI=1S/C17H13ClF7N5O2/c18-9-5-30(14(21)22)29-12(9)13(31)27-7-1-2-10(20)8(3-7)16(6-19)4-11(17(23,24)25)32-15(26)28-16/h1-3,5,11,14H,4,6H2,(H2,26,28)(H,27,31)/t11-,16+/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | 4.2 | n/a |
Amgen Inc.
US Patent
| Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic... |
US Patent US9296734 (2016)
BindingDB Entry DOI: 10.7270/Q2DR2TB3 |
More data for this
Ligand-Target Pair | |
Beta-secretase 1
(Homo sapiens (Human)) | BDBM214836
(US9296734, 36)Show SMILES NC1=N[C@@](CF)(C[C@H](O1)C(F)(F)F)c1cc(NC(=O)c2nn(cc2Cl)C(F)F)ccc1F |r,t:1| Show InChI InChI=1S/C17H13ClF7N5O2/c18-9-5-30(14(21)22)29-12(9)13(31)27-7-1-2-10(20)8(3-7)16(6-19)4-11(17(23,24)25)32-15(26)28-16/h1-3,5,11,14H,4,6H2,(H2,26,28)(H,27,31)/t11-,16+/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | 37 |
Amgen Inc.
US Patent
| Assay Description
The cell-based assay measures inhibition or reduction of Aβ40 in conditioned medium of test compound treated cells expressing amyloid precursor ... |
US Patent US9296734 (2016)
BindingDB Entry DOI: 10.7270/Q2DR2TB3 |
More data for this
Ligand-Target Pair | |
Cathepsin D
(Homo sapiens (Human)) | BDBM214836
(US9296734, 36)Show SMILES NC1=N[C@@](CF)(C[C@H](O1)C(F)(F)F)c1cc(NC(=O)c2nn(cc2Cl)C(F)F)ccc1F |r,t:1| Show InChI InChI=1S/C17H13ClF7N5O2/c18-9-5-30(14(21)22)29-12(9)13(31)27-7-1-2-10(20)8(3-7)16(6-19)4-11(17(23,24)25)32-15(26)28-16/h1-3,5,11,14H,4,6H2,(H2,26,28)(H,27,31)/t11-,16+/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.38E+6 | n/a | n/a | n/a | n/a | 3.5 | n/a |
Amgen Inc.
US Patent
| Assay Description
Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ... |
US Patent US9296734 (2016)
BindingDB Entry DOI: 10.7270/Q2DR2TB3 |
More data for this
Ligand-Target Pair | |