Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Beta-secretase 1
(Homo sapiens (Human)) | BDBM314756
(N-(3-(((1R,S), (5S,R), (6R,S))-3-amino-5- (fluorom...)Show SMILES NC1=N[C@](CF)([C@@H]2C[C@H]2O1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1Cl |r,t:1| Show InChI InChI=1S/C18H15Cl2FN4O2/c19-9-1-4-14(23-7-9)16(26)24-10-2-3-13(20)11(5-10)18(8-21)12-6-15(12)27-17(22)25-18/h1-5,7,12,15H,6,8H2,(H2,22,25)(H,24,26)/t12-,15-,18+/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 138 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic... |
US Patent US9611261 (2017)
BindingDB Entry DOI: 10.7270/Q21J9CW2 |
More data for this
Ligand-Target Pair | |
Cathepsin D
(Homo sapiens (Human)) | BDBM314756
(N-(3-(((1R,S), (5S,R), (6R,S))-3-amino-5- (fluorom...)Show SMILES NC1=N[C@](CF)([C@@H]2C[C@H]2O1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1Cl |r,t:1| Show InChI InChI=1S/C18H15Cl2FN4O2/c19-9-1-4-14(23-7-9)16(26)24-10-2-3-13(20)11(5-10)18(8-21)12-6-15(12)27-17(22)25-18/h1-5,7,12,15H,6,8H2,(H2,22,25)(H,24,26)/t12-,15-,18+/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 9.18E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description
Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ... |
US Patent US9611261 (2017)
BindingDB Entry DOI: 10.7270/Q21J9CW2 |
More data for this
Ligand-Target Pair | |