Found 4 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Kappa-type opioid receptor
(Homo sapiens (Human)) | BDBM133857
(US8846929, 22)Show SMILES NC1CCN(CC1)c1nc2ccccc2n(C2CCN(CC2)C2CCCCCCC2)c1=O Show InChI InChI=1S/C26H39N5O/c27-20-12-16-30(17-13-20)25-26(32)31(24-11-7-6-10-23(24)28-25)22-14-18-29(19-15-22)21-8-4-2-1-3-5-9-21/h6-7,10-11,20-22H,1-5,8-9,12-19,27H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| US Patent
| 30.4 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Purdue Pharma L.P.; Shionogi & Co., Ltd.
US Patent
| Assay Description
Radioligand dose displacement assays used 0.4-0.8nM [3H]-U69,593 (NEN; 40 Ci/mmole) with 10-20 ug membrane protein (recombinant kappa opioid receptor... |
US Patent US8846929 (2014)
BindingDB Entry DOI: 10.7270/Q2G44P04 |
More data for this
Ligand-Target Pair | |
Opioid growth factor receptor-like protein 1
(Homo sapiens (Human)) | BDBM133857
(US8846929, 22)Show SMILES NC1CCN(CC1)c1nc2ccccc2n(C2CCN(CC2)C2CCCCCCC2)c1=O Show InChI InChI=1S/C26H39N5O/c27-20-12-16-30(17-13-20)25-26(32)31(24-11-7-6-10-23(24)28-25)22-14-18-29(19-15-22)21-8-4-2-1-3-5-9-21/h6-7,10-11,20-22H,1-5,8-9,12-19,27H2 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 35.2 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Purdue Pharma L.P.; Shionogi & Co., Ltd.
US Patent
| Assay Description
Radioligand binding assays (screening and dose-displacement) used 0.1nM [3H]-nociceptin (NEN; 87.7 Cl/nimole) with 10-20 ug membrane protein in a fin... |
US Patent US8846929 (2014)
BindingDB Entry DOI: 10.7270/Q2G44P04 |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM133857
(US8846929, 22)Show SMILES NC1CCN(CC1)c1nc2ccccc2n(C2CCN(CC2)C2CCCCCCC2)c1=O Show InChI InChI=1S/C26H39N5O/c27-20-12-16-30(17-13-20)25-26(32)31(24-11-7-6-10-23(24)28-25)22-14-18-29(19-15-22)21-8-4-2-1-3-5-9-21/h6-7,10-11,20-22H,1-5,8-9,12-19,27H2 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 3.04E+3 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Purdue Pharma L.P.; Shionogi & Co., Ltd.
US Patent
| Assay Description
Radioligand dose-displacement binding assays for u-opioid receptors used 0.2nM[3H]-diprenorphine (NEN, Boston, Mass.), with 5-20mg membrane protein/w... |
US Patent US8846929 (2014)
BindingDB Entry DOI: 10.7270/Q2G44P04 |
More data for this
Ligand-Target Pair | |
Delta-type opioid receptor
(Homo sapiens (Human)) | BDBM133857
(US8846929, 22)Show SMILES NC1CCN(CC1)c1nc2ccccc2n(C2CCN(CC2)C2CCCCCCC2)c1=O Show InChI InChI=1S/C26H39N5O/c27-20-12-16-30(17-13-20)25-26(32)31(24-11-7-6-10-23(24)28-25)22-14-18-29(19-15-22)21-8-4-2-1-3-5-9-21/h6-7,10-11,20-22H,1-5,8-9,12-19,27H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 1.94E+4 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Purdue Pharma L.P.; Shionogi & Co., Ltd.
US Patent
| Assay Description
Radioligand dose-displacement assays used 0.2nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20ug membrane protein (recombinant delta opioid recepto... |
US Patent US8846929 (2014)
BindingDB Entry DOI: 10.7270/Q2G44P04 |
More data for this
Ligand-Target Pair | |