Found 7 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50155380
(-(2R)-[2-aminoacetamido]-3-(4-chlorophenyl)propion...)Show SMILES NCC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1 Show InChI InChI=1S/C28H34ClN5O2S/c29-23-9-7-21(8-10-23)18-25(32-27(35)19-30)28(36)34-15-13-33(14-16-34)26-6-2-1-4-22(26)20-31-12-11-24-5-3-17-37-24/h1-10,17,25,31H,11-16,18-20,30H2,(H,32,35)/t25-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 44 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description Tested for inhibition of binding to MC4 receptor |
Bioorg Med Chem Lett 14: 5605-9 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.055 BindingDB Entry DOI: 10.7270/Q2DB82K8 |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50155380
(-(2R)-[2-aminoacetamido]-3-(4-chlorophenyl)propion...)Show SMILES NCC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1 Show InChI InChI=1S/C28H34ClN5O2S/c29-23-9-7-21(8-10-23)18-25(32-27(35)19-30)28(36)34-15-13-33(14-16-34)26-6-2-1-4-22(26)20-31-12-11-24-5-3-17-37-24/h1-10,17,25,31H,11-16,18-20,30H2,(H,32,35)/t25-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 44 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description Displacement of [125]NDP-MSH from human MC4 receptor expressed in HEK293 cells |
J Med Chem 47: 6821-30 (2004)
Article DOI: 10.1021/jm049278i BindingDB Entry DOI: 10.7270/Q2610ZSQ |
More data for this Ligand-Target Pair | |
Melanocortin receptor 5
(Homo sapiens (Human)) | BDBM50155380
(-(2R)-[2-aminoacetamido]-3-(4-chlorophenyl)propion...)Show SMILES NCC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1 Show InChI InChI=1S/C28H34ClN5O2S/c29-23-9-7-21(8-10-23)18-25(32-27(35)19-30)28(36)34-15-13-33(14-16-34)26-6-2-1-4-22(26)20-31-12-11-24-5-3-17-37-24/h1-10,17,25,31H,11-16,18-20,30H2,(H,32,35)/t25-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 990 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description Displacement of [125]NDP-MSH from human MC5 receptor expressed in HEK293 cells |
J Med Chem 47: 6821-30 (2004)
Article DOI: 10.1021/jm049278i BindingDB Entry DOI: 10.7270/Q2610ZSQ |
More data for this Ligand-Target Pair | |
Melanocortin receptor 5
(Homo sapiens (Human)) | BDBM50155380
(-(2R)-[2-aminoacetamido]-3-(4-chlorophenyl)propion...)Show SMILES NCC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1 Show InChI InChI=1S/C28H34ClN5O2S/c29-23-9-7-21(8-10-23)18-25(32-27(35)19-30)28(36)34-15-13-33(14-16-34)26-6-2-1-4-22(26)20-31-12-11-24-5-3-17-37-24/h1-10,17,25,31H,11-16,18-20,30H2,(H,32,35)/t25-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 990 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description Binding affinity towards human melanocortin 5 receptor expressed in HEK 293 cells was determined by using [125I]NDP-MSH as radioligand |
Bioorg Med Chem Lett 14: 5605-9 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.055 BindingDB Entry DOI: 10.7270/Q2DB82K8 |
More data for this Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50155380
(-(2R)-[2-aminoacetamido]-3-(4-chlorophenyl)propion...)Show SMILES NCC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1 Show InChI InChI=1S/C28H34ClN5O2S/c29-23-9-7-21(8-10-23)18-25(32-27(35)19-30)28(36)34-15-13-33(14-16-34)26-6-2-1-4-22(26)20-31-12-11-24-5-3-17-37-24/h1-10,17,25,31H,11-16,18-20,30H2,(H,32,35)/t25-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description Displacement of [125]NDP-MSH from human MC3receptor expressed in HEK293 cells |
J Med Chem 47: 6821-30 (2004)
Article DOI: 10.1021/jm049278i BindingDB Entry DOI: 10.7270/Q2610ZSQ |
More data for this Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50155380
(-(2R)-[2-aminoacetamido]-3-(4-chlorophenyl)propion...)Show SMILES NCC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1 Show InChI InChI=1S/C28H34ClN5O2S/c29-23-9-7-21(8-10-23)18-25(32-27(35)19-30)28(36)34-15-13-33(14-16-34)26-6-2-1-4-22(26)20-31-12-11-24-5-3-17-37-24/h1-10,17,25,31H,11-16,18-20,30H2,(H,32,35)/t25-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description Binding affinity towards human melanocortin 3 receptor expressed in HEK 293 cells was determined by using [125I]NDP-MSH as radioligand |
Bioorg Med Chem Lett 14: 5605-9 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.055 BindingDB Entry DOI: 10.7270/Q2DB82K8 |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50155380
(-(2R)-[2-aminoacetamido]-3-(4-chlorophenyl)propion...)Show SMILES NCC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(CC1)c1ccccc1CNCCc1cccs1 Show InChI InChI=1S/C28H34ClN5O2S/c29-23-9-7-21(8-10-23)18-25(32-27(35)19-30)28(36)34-15-13-33(14-16-34)26-6-2-1-4-22(26)20-31-12-11-24-5-3-17-37-24/h1-10,17,25,31H,11-16,18-20,30H2,(H,32,35)/t25-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 580 | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description Agonist activity at human MC4 receptor expressed in HEK293 cells assessed as stimulation of cAMP production |
J Med Chem 47: 6821-30 (2004)
Article DOI: 10.1021/jm049278i BindingDB Entry DOI: 10.7270/Q2610ZSQ |
More data for this Ligand-Target Pair | |