Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Ribosomal protein S6 kinase beta-1 [T412E]
(Homo sapiens (Human)) | BDBM385992
(2-(1-(5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)pip...)Show SMILES NCC(C1CCN(CC1)c1ccnc2NCCCc12)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C22H27F3N4/c23-22(24,25)17-5-3-15(4-6-17)19(14-26)16-8-12-29(13-9-16)20-7-11-28-21-18(20)2-1-10-27-21/h3-7,11,16,19H,1-2,8-10,12-14,26H2,(H,27,28) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 62 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin at Madison
| Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com... |
J Med Chem 51: 7243-52 (2008)
BindingDB Entry DOI: 10.7270/Q26M394B |
More data for this
Ligand-Target Pair | |
Proline-rich AKT1 substrate 1
(Homo sapiens (Human)) | BDBM385992
(2-(1-(5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)pip...)Show SMILES NCC(C1CCN(CC1)c1ccnc2NCCCc12)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C22H27F3N4/c23-22(24,25)17-5-3-15(4-6-17)19(14-26)16-8-12-29(13-9-16)20-7-11-28-21-18(20)2-1-10-27-21/h3-7,11,16,19H,1-2,8-10,12-14,26H2,(H,27,28) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin at Madison
| Assay Description
A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu... |
J Med Chem 51: 7243-52 (2008)
BindingDB Entry DOI: 10.7270/Q26M394B |
More data for this
Ligand-Target Pair | |