Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Proline-rich AKT1 substrate 1
(Homo sapiens (Human)) | BDBM386017
(2-[1-(7,8-Dihydro-6H-pyrimido[5,4-b][1,4]oxazin-4-...)Show SMILES NCC(C1CCN(CC1)c1ncnc2NCCOc12)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C20H24F3N5O/c21-20(22,23)15-3-1-13(2-4-15)16(11-24)14-5-8-28(9-6-14)19-17-18(26-12-27-19)25-7-10-29-17/h1-4,12,14,16H,5-11,24H2,(H,25,26,27) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin at Madison
| Assay Description A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu... |
J Med Chem 51: 7243-52 (2008)
BindingDB Entry DOI: 10.7270/Q26M394B |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase beta-1 [T412E]
(Homo sapiens (Human)) | BDBM386017
(2-[1-(7,8-Dihydro-6H-pyrimido[5,4-b][1,4]oxazin-4-...)Show SMILES NCC(C1CCN(CC1)c1ncnc2NCCOc12)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C20H24F3N5O/c21-20(22,23)15-3-1-13(2-4-15)16(11-24)14-5-8-28(9-6-14)19-17-18(26-12-27-19)25-7-10-29-17/h1-4,12,14,16H,5-11,24H2,(H,25,26,27) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin at Madison
| Assay Description P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com... |
J Med Chem 51: 7243-52 (2008)
BindingDB Entry DOI: 10.7270/Q26M394B |
More data for this Ligand-Target Pair | |