Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Proline-rich AKT1 substrate 1
(Homo sapiens (Human)) | BDBM385994
(2-(1-(6,7-dihydro-5H-cyclopenta[b]pyrimidin-4-yl)p...)Show SMILES NCC(N1CCN(CC1)c1ncnc2CCCc12)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C20H24F3N5/c21-20(22,23)15-6-4-14(5-7-15)18(12-24)27-8-10-28(11-9-27)19-16-2-1-3-17(16)25-13-26-19/h4-7,13,18H,1-3,8-12,24H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin at Madison
| Assay Description A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu... |
J Med Chem 51: 7243-52 (2008)
BindingDB Entry DOI: 10.7270/Q26M394B |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase beta-1 [T412E]
(Homo sapiens (Human)) | BDBM385994
(2-(1-(6,7-dihydro-5H-cyclopenta[b]pyrimidin-4-yl)p...)Show SMILES NCC(N1CCN(CC1)c1ncnc2CCCc12)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C20H24F3N5/c21-20(22,23)15-6-4-14(5-7-15)18(12-24)27-8-10-28(11-9-27)19-16-2-1-3-17(16)25-13-26-19/h4-7,13,18H,1-3,8-12,24H2 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin at Madison
| Assay Description P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com... |
J Med Chem 51: 7243-52 (2008)
BindingDB Entry DOI: 10.7270/Q26M394B |
More data for this Ligand-Target Pair | |