Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Proline-rich AKT1 substrate 1
(Homo sapiens (Human)) | BDBM386044
(4-(4-(2-amino)-1-(3,4-difluorophenyl)ethyl)piperaz...)Show SMILES NCC(N1CCN(CC1)c1ncnc2NCC(=O)Nc12)c1ccc(F)c(F)c1 Show InChI InChI=1S/C18H21F2N7O/c19-12-2-1-11(7-13(12)20)14(8-21)26-3-5-27(6-4-26)18-16-17(23-10-24-18)22-9-15(28)25-16/h1-2,7,10,14H,3-6,8-9,21H2,(H,25,28)(H,22,23,24) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin at Madison
| Assay Description A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu... |
J Med Chem 51: 7243-52 (2008)
BindingDB Entry DOI: 10.7270/Q26M394B |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase beta-1 [T412E]
(Homo sapiens (Human)) | BDBM386044
(4-(4-(2-amino)-1-(3,4-difluorophenyl)ethyl)piperaz...)Show SMILES NCC(N1CCN(CC1)c1ncnc2NCC(=O)Nc12)c1ccc(F)c(F)c1 Show InChI InChI=1S/C18H21F2N7O/c19-12-2-1-11(7-13(12)20)14(8-21)26-3-5-27(6-4-26)18-16-17(23-10-24-18)22-9-15(28)25-16/h1-2,7,10,14H,3-6,8-9,21H2,(H,25,28)(H,22,23,24) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin at Madison
| Assay Description P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com... |
J Med Chem 51: 7243-52 (2008)
BindingDB Entry DOI: 10.7270/Q26M394B |
More data for this Ligand-Target Pair | |