Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Proline-rich AKT1 substrate 1
(Homo sapiens (Human)) | BDBM386011
(2-(4-Chloro-phenyl)-2-[4-(5,6,7,8-tetrahydro-pyrid...)Show InChI InChI=1S/C19H25ClN6/c20-15-5-3-14(4-6-15)17(12-21)25-8-10-26(11-9-25)19-16-2-1-7-22-18(16)23-13-24-19/h3-6,13,17H,1-2,7-12,21H2,(H,22,23,24) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 62 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin at Madison
| Assay Description A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu... |
J Med Chem 51: 7243-52 (2008)
BindingDB Entry DOI: 10.7270/Q26M394B |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase beta-1 [T412E]
(Homo sapiens (Human)) | BDBM386011
(2-(4-Chloro-phenyl)-2-[4-(5,6,7,8-tetrahydro-pyrid...)Show InChI InChI=1S/C19H25ClN6/c20-15-5-3-14(4-6-15)17(12-21)25-8-10-26(11-9-25)19-16-2-1-7-22-18(16)23-13-24-19/h3-6,13,17H,1-2,7-12,21H2,(H,22,23,24) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin at Madison
| Assay Description P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com... |
J Med Chem 51: 7243-52 (2008)
BindingDB Entry DOI: 10.7270/Q26M394B |
More data for this Ligand-Target Pair | |