Found 7 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Voltage-dependent T-type calcium channel subunit alpha-1H
(Homo sapiens (Human)) | BDBM164202
(US9688615, 13)Show SMILES NCCC(=O)N1CC(Cc2nc3c(cc(cc3[nH]2)C(F)(F)F)C(F)(F)F)C1 Show InChI InChI=1S/C16H16F6N4O/c17-15(18,19)9-4-10(16(20,21)22)14-11(5-9)24-12(25-14)3-8-6-26(7-8)13(27)1-2-23/h4-5,8H,1-3,6-7,23H2,(H,24,25) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 5.29E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
SRMLSC
US Patent
| Assay Description Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in... |
US Patent US9688615 (2017)
BindingDB Entry DOI: 10.7270/Q27S7KXH |
More data for this Ligand-Target Pair | |
Voltage-dependent N-type calcium channel subunit alpha-1B
(Homo sapiens (Human)) | BDBM164202
(US9688615, 13)Show SMILES NCCC(=O)N1CC(Cc2nc3c(cc(cc3[nH]2)C(F)(F)F)C(F)(F)F)C1 Show InChI InChI=1S/C16H16F6N4O/c17-15(18,19)9-4-10(16(20,21)22)14-11(5-9)24-12(25-14)3-8-6-26(7-8)13(27)1-2-23/h4-5,8H,1-3,6-7,23H2,(H,24,25) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
SRMLSC
US Patent
| Assay Description Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in... |
US Patent US9688615 (2017)
BindingDB Entry DOI: 10.7270/Q27S7KXH |
More data for this Ligand-Target Pair | |
Voltage-dependent T-type calcium channel subunit alpha-1G
(Homo sapiens (Human)) | BDBM164202
(US9688615, 13)Show SMILES NCCC(=O)N1CC(Cc2nc3c(cc(cc3[nH]2)C(F)(F)F)C(F)(F)F)C1 Show InChI InChI=1S/C16H16F6N4O/c17-15(18,19)9-4-10(16(20,21)22)14-11(5-9)24-12(25-14)3-8-6-26(7-8)13(27)1-2-23/h4-5,8H,1-3,6-7,23H2,(H,24,25) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
SRMLSC
US Patent
| Assay Description Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in... |
US Patent US9688615 (2017)
BindingDB Entry DOI: 10.7270/Q27S7KXH |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1C
(Homo sapiens (Human)) | BDBM164202
(US9688615, 13)Show SMILES NCCC(=O)N1CC(Cc2nc3c(cc(cc3[nH]2)C(F)(F)F)C(F)(F)F)C1 Show InChI InChI=1S/C16H16F6N4O/c17-15(18,19)9-4-10(16(20,21)22)14-11(5-9)24-12(25-14)3-8-6-26(7-8)13(27)1-2-23/h4-5,8H,1-3,6-7,23H2,(H,24,25) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.4 | n/a |
SRMLSC
US Patent
| Assay Description To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b... |
US Patent US9688615 (2017)
BindingDB Entry DOI: 10.7270/Q27S7KXH |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1C
(Homo sapiens (Human)) | BDBM164202
(US9688615, 13)Show SMILES NCCC(=O)N1CC(Cc2nc3c(cc(cc3[nH]2)C(F)(F)F)C(F)(F)F)C1 Show InChI InChI=1S/C16H16F6N4O/c17-15(18,19)9-4-10(16(20,21)22)14-11(5-9)24-12(25-14)3-8-6-26(7-8)13(27)1-2-23/h4-5,8H,1-3,6-7,23H2,(H,24,25) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.4 | n/a |
SRMLSC
US Patent
| Assay Description To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b... |
US Patent US9688615 (2017)
BindingDB Entry DOI: 10.7270/Q27S7KXH |
More data for this Ligand-Target Pair | |
Voltage-dependent N-type calcium channel subunit alpha-1B
(Homo sapiens (Human)) | BDBM164202
(US9688615, 13)Show SMILES NCCC(=O)N1CC(Cc2nc3c(cc(cc3[nH]2)C(F)(F)F)C(F)(F)F)C1 Show InChI InChI=1S/C16H16F6N4O/c17-15(18,19)9-4-10(16(20,21)22)14-11(5-9)24-12(25-14)3-8-6-26(7-8)13(27)1-2-23/h4-5,8H,1-3,6-7,23H2,(H,24,25) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
SRMLSC
US Patent
| Assay Description Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in... |
US Patent US9688615 (2017)
BindingDB Entry DOI: 10.7270/Q27S7KXH |
More data for this Ligand-Target Pair | |
Voltage-dependent T-type calcium channel subunit alpha-1H
(Homo sapiens (Human)) | BDBM164202
(US9688615, 13)Show SMILES NCCC(=O)N1CC(Cc2nc3c(cc(cc3[nH]2)C(F)(F)F)C(F)(F)F)C1 Show InChI InChI=1S/C16H16F6N4O/c17-15(18,19)9-4-10(16(20,21)22)14-11(5-9)24-12(25-14)3-8-6-26(7-8)13(27)1-2-23/h4-5,8H,1-3,6-7,23H2,(H,24,25) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
SRMLSC
US Patent
| Assay Description Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in... |
US Patent US9688615 (2017)
BindingDB Entry DOI: 10.7270/Q27S7KXH |
More data for this Ligand-Target Pair | |