Found 5 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50247069
(2-(7-(benzyloxy)-1H-indol-3-yl)ethanamine | CHEMBL...)Show InChI InChI=1S/C17H18N2O/c18-10-9-14-11-19-17-15(14)7-4-8-16(17)20-12-13-5-2-1-3-6-13/h1-8,11,19H,9-10,12,18H2 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3.34E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Renovis, Inc.
Curated by ChEMBL
| Assay Description Antagonist activity at human TRPM8 receptor expressed in human T-REx-293 cells assessed as inhibition of menthol-induced 45calcium influx treated 5 m... |
Bioorg Med Chem Lett 20: 7076-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.099 BindingDB Entry DOI: 10.7270/Q2DN459H |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50247069
(2-(7-(benzyloxy)-1H-indol-3-yl)ethanamine | CHEMBL...)Show InChI InChI=1S/C17H18N2O/c18-10-9-14-11-19-17-15(14)7-4-8-16(17)20-12-13-5-2-1-3-6-13/h1-8,11,19H,9-10,12,18H2 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 8.93E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Renovis, Inc.
Curated by ChEMBL
| Assay Description Antagonist activity at human TRPM8 receptor expressed in human T-REx-293 cells assessed as inhibition of icilin-induced 45calcium influx treated 5 mi... |
Bioorg Med Chem Lett 20: 7076-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.099 BindingDB Entry DOI: 10.7270/Q2DN459H |
More data for this Ligand-Target Pair | |
Leukotriene A-4 hydrolase
(Homo sapiens (Human)) | BDBM50247069
(2-(7-(benzyloxy)-1H-indol-3-yl)ethanamine | CHEMBL...)Show InChI InChI=1S/C17H18N2O/c18-10-9-14-11-19-17-15(14)7-4-8-16(17)20-12-13-5-2-1-3-6-13/h1-8,11,19H,9-10,12,18H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.25E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description Inhibition of aminopeptidase activity of human leukotriene A4 hydrolase assessed as para-nitroanilide release by spectrophotometry |
J Med Chem 51: 7882-8 (2008)
Article DOI: 10.1021/jm8010096 BindingDB Entry DOI: 10.7270/Q2VH5NQQ |
More data for this Ligand-Target Pair | |
Phospholipase A2, membrane associated
(Homo sapiens (Human)) | BDBM50247069
(2-(7-(benzyloxy)-1H-indol-3-yl)ethanamine | CHEMBL...)Show InChI InChI=1S/C17H18N2O/c18-10-9-14-11-19-17-15(14)7-4-8-16(17)20-12-13-5-2-1-3-6-13/h1-8,11,19H,9-10,12,18H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 5.25E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description Inhibition of human nonpancreatic secretory phospholipase A2 |
J Med Chem 51: 7882-8 (2008)
Article DOI: 10.1021/jm8010096 BindingDB Entry DOI: 10.7270/Q2VH5NQQ |
More data for this Ligand-Target Pair | |
Leukotriene A-4 hydrolase
(Homo sapiens (Human)) | BDBM50247069
(2-(7-(benzyloxy)-1H-indol-3-yl)ethanamine | CHEMBL...)Show InChI InChI=1S/C17H18N2O/c18-10-9-14-11-19-17-15(14)7-4-8-16(17)20-12-13-5-2-1-3-6-13/h1-8,11,19H,9-10,12,18H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.17E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Peking University
Curated by ChEMBL
| Assay Description Inhibition of epoxide hydrolase activity of human leukotriene A4 hydrolase assessed as LTB4 level by ELISA |
J Med Chem 51: 7882-8 (2008)
Article DOI: 10.1021/jm8010096 BindingDB Entry DOI: 10.7270/Q2VH5NQQ |
More data for this Ligand-Target Pair | |