Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Leukotriene A-4 hydrolase
(Homo sapiens (Human)) | BDBM50294164
(1-(2,2'-bithiophen-5-yl)methanamine | 2,2'-bithiop...)Show InChI InChI=1S/C9H9NS2/c10-6-7-3-4-9(12-7)8-2-1-5-11-8/h1-5H,6,10H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 3.89E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE biostructures, Inc.
Curated by ChEMBL
| Assay Description Inhibition of peptidase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRARE |
J Med Chem 52: 4694-715 (2009)
Article DOI: 10.1021/jm900259h BindingDB Entry DOI: 10.7270/Q2F47P6N |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Leukotriene A-4 hydrolase
(Homo sapiens (Human)) | BDBM50294164
(1-(2,2'-bithiophen-5-yl)methanamine | 2,2'-bithiop...)Show InChI InChI=1S/C9H9NS2/c10-6-7-3-4-9(12-7)8-2-1-5-11-8/h1-5H,6,10H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 7.52E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE biostructures, Inc.
Curated by ChEMBL
| Assay Description Inhibition of hydrolase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRARE assessed as LTB4 formation by tandem quadrupo... |
J Med Chem 52: 4694-715 (2009)
Article DOI: 10.1021/jm900259h BindingDB Entry DOI: 10.7270/Q2F47P6N |
More data for this Ligand-Target Pair | 3D Structure (crystal) |