Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 447.2 BDBM50001206

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA polymerase alpha catalytic subunit (Homo sapiens (Human))	BDBM50001206 (CHEMBL3236422) Show SMILES Nc1ccn([C@@H]2O[C@H](COP(O)(=O)NC(=O)c3cccnc3)[C@@H](O)C2(F)F)c(=O)n1 |r| Show InChI InChI=1S/C15H16F2N5O7P/c16-15(17)11(23)9(29-13(15)22-5-3-10(18)20-14(22)25)7-28-30(26,27)21-12(24)8-2-1-4-19-6-8/h1-6,9,11,13,23H,7H2,(H2,18,20,25)(H2,21,24,26,27)/t9-,11-,13-/m1/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.50E+5	n/a	n/a	n/a	n/a
Polish Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of human DNA polymerase alpha using dCTP as substrate assessed as single base extension reaction after 2 hrs				Bioorg Med Chem 22: 2133-40 (2014) Article DOI: 10.1016/j.bmc.2014.02.034 BindingDB Entry DOI: 10.7270/Q20866TW
					More data for this Ligand-Target Pair