Found 3 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM169120
(US9079866, 521 | US9745328, Compound 521 | US98848...)Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccc(cc1C(=O)N1CCOCC1)C(F)(F)F Show InChI InChI=1S/C22H18F4N4O2/c23-18-9-13(1-3-16(18)19-11-29-20(27)12-28-19)15-4-2-14(22(24,25)26)10-17(15)21(31)30-5-7-32-8-6-30/h1-4,9-12H,5-8H2,(H2,27,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN PHARMACEUTICA NV
US Patent
| Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai... |
US Patent US9079866 (2015)
BindingDB Entry DOI: 10.7270/Q2FF3R3Q |
More data for this Ligand-Target Pair | |
Flap endonuclease 1
(Homo sapiens (Human)) | BDBM169120
(US9079866, 521 | US9745328, Compound 521 | US98848...)Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccc(cc1C(=O)N1CCOCC1)C(F)(F)F Show InChI InChI=1S/C22H18F4N4O2/c23-18-9-13(1-3-16(18)19-11-29-20(27)12-28-19)15-4-2-14(22(24,25)26)10-17(15)21(31)30-5-7-32-8-6-30/h1-4,9-12H,5-8H2,(H2,27,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma... |
US Patent US9745328 (2017)
BindingDB Entry DOI: 10.7270/Q2H13446 |
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM169120
(US9079866, 521 | US9745328, Compound 521 | US98848...)Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccc(cc1C(=O)N1CCOCC1)C(F)(F)F Show InChI InChI=1S/C22H18F4N4O2/c23-18-9-13(1-3-16(18)19-11-29-20(27)12-28-19)15-4-2-14(22(24,25)26)10-17(15)21(31)30-5-7-32-8-6-30/h1-4,9-12H,5-8H2,(H2,27,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN PHARMACEUTICA NV
US Patent
| Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai... |
US Patent US9884878 (2018)
BindingDB Entry DOI: 10.7270/Q2R78H8P |
More data for this Ligand-Target Pair | |