Found 3 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM169466
(US9079866, 111 | US9745328, Compound 111 | US98848...)Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)N1CC[C@@H](CO)C1 |r| Show InChI InChI=1S/C21H21FN4O3S/c22-18-9-15(5-6-17(18)19-10-25-21(23)11-24-19)16-3-1-2-4-20(16)30(28,29)26-8-7-14(12-26)13-27/h1-6,9-11,14,27H,7-8,12-13H2,(H2,23,25)/t14-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN PHARMACEUTICA NV
US Patent
| Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai... |
US Patent US9079866 (2015)
BindingDB Entry DOI: 10.7270/Q2FF3R3Q |
More data for this Ligand-Target Pair | |
Flap endonuclease 1
(Homo sapiens (Human)) | BDBM169466
(US9079866, 111 | US9745328, Compound 111 | US98848...)Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)N1CC[C@@H](CO)C1 |r| Show InChI InChI=1S/C21H21FN4O3S/c22-18-9-15(5-6-17(18)19-10-25-21(23)11-24-19)16-3-1-2-4-20(16)30(28,29)26-8-7-14(12-26)13-27/h1-6,9-11,14,27H,7-8,12-13H2,(H2,23,25)/t14-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma... |
US Patent US9745328 (2017)
BindingDB Entry DOI: 10.7270/Q2H13446 |
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM169466
(US9079866, 111 | US9745328, Compound 111 | US98848...)Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)N1CC[C@@H](CO)C1 |r| Show InChI InChI=1S/C21H21FN4O3S/c22-18-9-15(5-6-17(18)19-10-25-21(23)11-24-19)16-3-1-2-4-20(16)30(28,29)26-8-7-14(12-26)13-27/h1-6,9-11,14,27H,7-8,12-13H2,(H2,23,25)/t14-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN PHARMACEUTICA NV
US Patent
| Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai... |
US Patent US9884878 (2018)
BindingDB Entry DOI: 10.7270/Q2R78H8P |
More data for this Ligand-Target Pair | |