Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Bifunctional dihydrofolate reductase-thymidylate synthase
(Plasmodium falciparum (isolate K1 / Thailand)) | BDBM50452175
(CHEMBL4218788)Show SMILES Nc1nc(N)c2cc(NCc3ccc(CCNC(=O)c4ccc(F)cc4)cc3)ccc2n1 Show InChI InChI=1S/C24H23FN6O/c25-18-7-5-17(6-8-18)23(32)28-12-11-15-1-3-16(4-2-15)14-29-19-9-10-21-20(13-19)22(26)31-24(27)30-21/h1-10,13,29H,11-12,14H2,(H,28,32)(H4,26,27,30,31) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 118 | n/a | n/a | n/a | n/a | n/a | n/a |
East China University of Science and Technology
Curated by ChEMBL
| Assay Description
Inhibition of Plasmodium falciparum DHFR using DHF as substrate preincubated for 15 mins followed DHF addition measured after 15 mins by spectrophoto... |
Bioorg Med Chem 25: 6467-6478 (2017)
Article DOI: 10.1016/j.bmc.2017.10.017
BindingDB Entry DOI: 10.7270/Q2D50QJX |
More data for this
Ligand-Target Pair | |
Cysteine proteinase falcipain 2a
(Plasmodium falciparum) | BDBM50452175
(CHEMBL4218788)Show SMILES Nc1nc(N)c2cc(NCc3ccc(CCNC(=O)c4ccc(F)cc4)cc3)ccc2n1 Show InChI InChI=1S/C24H23FN6O/c25-18-7-5-17(6-8-18)23(32)28-12-11-15-1-3-16(4-2-15)14-29-19-9-10-21-20(13-19)22(26)31-24(27)30-21/h1-10,13,29H,11-12,14H2,(H,28,32)(H4,26,27,30,31) | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
East China University of Science and Technology
Curated by ChEMBL
| Assay Description
Inhibition of Plasmodium falciparum FP2 using Z-Leu-Arg-AMC as substrate preincubated for 30 min followed by substrate addition measured after 30 min... |
Bioorg Med Chem 25: 6467-6478 (2017)
Article DOI: 10.1016/j.bmc.2017.10.017
BindingDB Entry DOI: 10.7270/Q2D50QJX |
More data for this
Ligand-Target Pair | |