Found 3 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM169391
(US9079866, 796 | US9745328, Compound 796 | US98848...)Show SMILES Nc1ncc(cn1)-c1ccc(cc1F)-c1ccc(cc1C(=O)N1CCC(O)CC1)C(F)(F)F Show InChI InChI=1S/C23H20F4N4O2/c24-20-9-13(1-3-18(20)14-11-29-22(28)30-12-14)17-4-2-15(23(25,26)27)10-19(17)21(33)31-7-5-16(32)6-8-31/h1-4,9-12,16,32H,5-8H2,(H2,28,29,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| US Patent
| 391 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN PHARMACEUTICA NV
US Patent
| Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai... |
US Patent US9884878 (2018)
BindingDB Entry DOI: 10.7270/Q2R78H8P |
More data for this
Ligand-Target Pair | |
Flap endonuclease 1
(Homo sapiens (Human)) | BDBM169391
(US9079866, 796 | US9745328, Compound 796 | US98848...)Show SMILES Nc1ncc(cn1)-c1ccc(cc1F)-c1ccc(cc1C(=O)N1CCC(O)CC1)C(F)(F)F Show InChI InChI=1S/C23H20F4N4O2/c24-20-9-13(1-3-18(20)14-11-29-22(28)30-12-14)17-4-2-15(23(25,26)27)10-19(17)21(33)31-7-5-16(32)6-8-31/h1-4,9-12,16,32H,5-8H2,(H2,28,29,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 391 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description
The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma... |
US Patent US9745328 (2017)
BindingDB Entry DOI: 10.7270/Q2H13446 |
More data for this
Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM169391
(US9079866, 796 | US9745328, Compound 796 | US98848...)Show SMILES Nc1ncc(cn1)-c1ccc(cc1F)-c1ccc(cc1C(=O)N1CCC(O)CC1)C(F)(F)F Show InChI InChI=1S/C23H20F4N4O2/c24-20-9-13(1-3-18(20)14-11-29-22(28)30-12-14)17-4-2-15(23(25,26)27)10-19(17)21(33)31-7-5-16(32)6-8-31/h1-4,9-12,16,32H,5-8H2,(H2,28,29,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 391 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN PHARMACEUTICA NV
US Patent
| Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai... |
US Patent US9079866 (2015)
BindingDB Entry DOI: 10.7270/Q2FF3R3Q |
More data for this
Ligand-Target Pair | |