Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 323.3 BDBM363955

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase kinase 4 (Homo sapiens (Human))	BDBM363955 (6-[3-fluoro-5-(pyrrolidin-1-ylmethyl)phenyl]pyrido...) Show SMILES Nc1ncnc2ccc(nc12)-c1cc(F)cc(CN2CCCC2)c1 Show InChI InChI=1S/C18H18FN5/c19-14-8-12(10-24-5-1-2-6-24)7-13(9-14)15-3-4-16-17(23-15)18(20)22-11-21-16/h3-4,7-9,11H,1-2,5-6,10H2,(H2,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	554	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research					Assay Description The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...				J Med Chem 46: 3709-27 (2003) BindingDB Entry DOI: 10.7270/Q2VH5R4B
					More data for this Ligand-Target Pair