Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 366.4 BDBM364073

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase kinase 4 (Homo sapiens (Human))	BDBM364073 (6-[3-fluoro-5-[(2-pyrrolidin-1-ylethylamino)methyl...) Show SMILES Nc1ncnc2ccc(nc12)-c1cc(F)cc(CNCCN2CCCC2)c1 Show InChI InChI=1S/C20H23FN6/c21-16-10-14(12-23-5-8-27-6-1-2-7-27)9-15(11-16)17-3-4-18-19(26-17)20(22)25-13-24-18/h3-4,9-11,13,23H,1-2,5-8,12H2,(H2,22,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	66.9	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research					Assay Description The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...				J Med Chem 46: 3709-27 (2003) BindingDB Entry DOI: 10.7270/Q2VH5R4B
					More data for this Ligand-Target Pair