Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Metabotropic glutamate receptor 1
(RAT) | BDBM50296677
(Adamantan-1-yl-(2-quinolin-3-yl-cyclopropyl)-metha...)Show SMILES O=C(C1CC1c1cnc2ccccc2c1)C12CC3CC(CC(C3)C1)C2 |THB:20:19:16:22.21.23,20:21:18.19.24:16,1:15:18:22.20.21,23:21:18:24.15.16,23:15:18:22.20.21| Show InChI InChI=1S/C23H25NO/c25-22(23-10-14-5-15(11-23)7-16(6-14)12-23)20-9-19(20)18-8-17-3-1-2-4-21(17)24-13-18/h1-4,8,13-16,19-20H,5-7,9-12H2 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 137 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merz Pharmaceuticals GmbH
Curated by ChEMBL
| Assay Description Displacement of [3H]E-3-(2-chloro-8-methylquinolin-3-yl)-1-(thiophen-2-yl)prop-2-en-1-one from mGluR1 in rat cerebellar membrane after 14 to 16 hrs b... |
Bioorg Med Chem 17: 5708-15 (2009)
Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30 |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50296677
(Adamantan-1-yl-(2-quinolin-3-yl-cyclopropyl)-metha...)Show SMILES O=C(C1CC1c1cnc2ccccc2c1)C12CC3CC(CC(C3)C1)C2 |THB:20:19:16:22.21.23,20:21:18.19.24:16,1:15:18:22.20.21,23:21:18:24.15.16,23:15:18:22.20.21| Show InChI InChI=1S/C23H25NO/c25-22(23-10-14-5-15(11-23)7-16(6-14)12-23)20-9-19(20)18-8-17-3-1-2-4-21(17)24-13-18/h1-4,8,13-16,19-20H,5-7,9-12H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merz Pharmaceuticals GmbH
Curated by ChEMBL
| Assay Description Displacement of [3H]MPEP from mGluR5 in rat cortical membrane after 60 mins by liquid scintillation counting |
Bioorg Med Chem 17: 5708-15 (2009)
Article DOI: 10.1016/j.bmc.2009.05.072 BindingDB Entry DOI: 10.7270/Q2416X30 |
More data for this Ligand-Target Pair | |