Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Leukotriene A-4 hydrolase
(Homo sapiens (Human)) | BDBM327156
((1-{4-[(2S)-2,3-dihydro-1,4- benzodioxin-2- yl]b...)Show SMILES O=C(C1CCN(Cc2ccc(cc2)[C@H]2COc3ccccc3O2)CC1)N1CCOCC1 |r| Show InChI InChI=1S/C25H30N2O4/c28-25(27-13-15-29-16-14-27)21-9-11-26(12-10-21)17-19-5-7-20(8-6-19)24-18-30-22-3-1-2-4-23(22)31-24/h1-8,21,24H,9-18H2/t24-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.120 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ... |
US Patent US9662339 (2017)
BindingDB Entry DOI: 10.7270/Q2GT5Q8D |
More data for this Ligand-Target Pair | |
Leukotriene A-4 hydrolase
(Homo sapiens (Human)) | BDBM327062
(US9662339, 37 | {1-[4-(2,3-dihydro-1,4- benzodiox...)Show SMILES O=C(C1CCN(Cc2ccc(cc2)C2COc3ccccc3O2)CC1)N1CCOCC1 Show InChI InChI=1S/C25H30N2O4/c28-25(27-13-15-29-16-14-27)21-9-11-26(12-10-21)17-19-5-7-20(8-6-19)24-18-30-22-3-1-2-4-23(22)31-24/h1-8,21,24H,9-18H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 1.05 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ... |
US Patent US9662339 (2017)
BindingDB Entry DOI: 10.7270/Q2GT5Q8D |
More data for this Ligand-Target Pair | |