Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Cysteinyl leukotriene receptor 1
(GUINEA PIG) | BDBM50084803
(2-[4-(Quinolin-2-ylmethoxy)-phenyl]-N-[4-(1H-tetra...)Show SMILES O=C(Cc1ccc(OCc2ccc3ccccc3n2)cc1)NCc1ccc(cc1)-c1nnn[nH]1 Show InChI InChI=1S/C26H22N6O2/c33-25(27-16-19-5-9-21(10-6-19)26-29-31-32-30-26)15-18-7-13-23(14-8-18)34-17-22-12-11-20-3-1-2-4-24(20)28-22/h1-14H,15-17H2,(H,27,33)(H,29,30,31,32) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 250 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratorios Menarini
Curated by ChEMBL
| Assay Description In vitro binding affinity towards Cysteinyl leukotriene D4 receptor by using [3H]-LTD4 binding assay in guinea pig lung membranes |
J Med Chem 43: 392-400 (2000)
BindingDB Entry DOI: 10.7270/Q2DJ5DVX |
More data for this Ligand-Target Pair | |
Cysteinyl leukotriene receptor 1
(Homo sapiens (Human)) | BDBM50084803
(2-[4-(Quinolin-2-ylmethoxy)-phenyl]-N-[4-(1H-tetra...)Show SMILES O=C(Cc1ccc(OCc2ccc3ccccc3n2)cc1)NCc1ccc(cc1)-c1nnn[nH]1 Show InChI InChI=1S/C26H22N6O2/c33-25(27-16-19-5-9-21(10-6-19)26-29-31-32-30-26)15-18-7-13-23(14-8-18)34-17-22-12-11-20-3-1-2-4-24(20)28-22/h1-14H,15-17H2,(H,27,33)(H,29,30,31,32) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Zhejiang University
Curated by ChEMBL
| Assay Description Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before L... |
Bioorg Med Chem 18: 5519-27 (2010)
Article DOI: 10.1016/j.bmc.2010.06.047 BindingDB Entry DOI: 10.7270/Q26D5TZ0 |
More data for this Ligand-Target Pair | |