Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 438.5 BDBM50205498

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein-serine O-palmitoleoyltransferase porcupine (Mus musculus)	BDBM50205498 (CHEMBL3981277) Show SMILES O=C(Cn1nnc(c1-c1ccccc1)-c1ccncc1)Nc1ccc(cn1)-c1ccsc1 Show InChI InChI=1S/C24H18N6OS/c31-22(27-21-7-6-19(14-26-21)20-10-13-32-16-20)15-30-24(18-4-2-1-3-5-18)23(28-29-30)17-8-11-25-12-9-17/h1-14,16H,15H2,(H,26,27,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.650	n/a	n/a	n/a	n/a
UT Southwestern Medical Center Curated by ChEMBL					Assay Description Inhibition of porcupine-mediated Wnt signaling in mouse L-cells after 24 hrs by springerImage-Topflash reporter assay				Bioorg Med Chem Lett 26: 5891-5895 (2016) Article DOI: 10.1016/j.bmcl.2016.11.012 BindingDB Entry DOI: 10.7270/Q2959KJR
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