Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 438.5 BDBM50205484

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein-serine O-palmitoleoyltransferase porcupine (Mus musculus)	BDBM50205484 (CHEMBL3901161) Show SMILES O=C(Cn1nnc(c1-c1ccccc1)-c1ccncc1)Nc1ncc(s1)-c1ccccc1 Show InChI InChI=1S/C24H18N6OS/c31-21(27-24-26-15-20(32-24)17-7-3-1-4-8-17)16-30-23(19-9-5-2-6-10-19)22(28-29-30)18-11-13-25-14-12-18/h1-15H,16H2,(H,26,27,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	8.00E+4	n/a	n/a	n/a	n/a
UT Southwestern Medical Center Curated by ChEMBL					Assay Description Inhibition of porcupine-mediated Wnt signaling in mouse L-cells after 24 hrs by springerImage-Topflash reporter assay				Bioorg Med Chem Lett 26: 5891-5895 (2016) Article DOI: 10.1016/j.bmcl.2016.11.012 BindingDB Entry DOI: 10.7270/Q2959KJR
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