Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Prostaglandin E synthase
(Homo sapiens (Human)) | BDBM50337666
(1-benzyl-3-(cyclopropylmethyl)-1-(3-(phenylethynyl...)Show SMILES O=C(NCC1CC1)N(Cc1ccccc1)Cc1cccc(c1)C#Cc1ccccc1 Show InChI InChI=1S/C27H26N2O/c30-27(28-19-24-16-17-24)29(20-25-10-5-2-6-11-25)21-26-13-7-12-23(18-26)15-14-22-8-3-1-4-9-22/h1-13,18,24H,16-17,19-21H2,(H,28,30) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Center for Therapeutic Research
Curated by ChEMBL
| Assay Description Inhibition of mPGES1 |
Bioorg Med Chem Lett 21: 1488-92 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.006 BindingDB Entry DOI: 10.7270/Q2XS5VNP |
More data for this Ligand-Target Pair | |
Prostaglandin E synthase
(Homo sapiens (Human)) | BDBM50337666
(1-benzyl-3-(cyclopropylmethyl)-1-(3-(phenylethynyl...)Show SMILES O=C(NCC1CC1)N(Cc1ccccc1)Cc1cccc(c1)C#Cc1ccccc1 Show InChI InChI=1S/C27H26N2O/c30-27(28-19-24-16-17-24)29(20-25-10-5-2-6-11-25)21-26-13-7-12-23(18-26)15-14-22-8-3-1-4-9-22/h1-13,18,24H,16-17,19-21H2,(H,28,30) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Center for Therapeutic Research
Curated by ChEMBL
| Assay Description Inhibition of mPGES1 in IL-1beta treated human A549 cell microsome assessed as inhibition of PGE2 production after 1 min in presence of 50% FBS |
Bioorg Med Chem Lett 21: 1488-92 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.006 BindingDB Entry DOI: 10.7270/Q2XS5VNP |
More data for this Ligand-Target Pair | |