Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Cysteinyl leukotriene receptor 1
(GUINEA PIG) | BDBM50084793
(4-Oxo-2-(1H-tetrazol-5-yl)-4H-chromene-8-carboxyli...)Show SMILES O=C(NCc1ccc(OCc2ccc3ccccc3n2)cc1)c1cccc2c1oc(cc2=O)-c1nnn[nH]1 Show InChI InChI=1S/C28H20N6O4/c35-24-14-25(27-31-33-34-32-27)38-26-21(24)5-3-6-22(26)28(36)29-15-17-8-12-20(13-9-17)37-16-19-11-10-18-4-1-2-7-23(18)30-19/h1-14H,15-16H2,(H,29,36)(H,31,32,33,34) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| 86 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratorios Menarini
Curated by ChEMBL
| Assay Description
In vitro binding affinity towards Cysteinyl leukotriene D4 receptor by using [3H]-LTD4 binding assay in guinea pig lung membranes |
J Med Chem 43: 392-400 (2000)
BindingDB Entry DOI: 10.7270/Q2DJ5DVX |
More data for this
Ligand-Target Pair | |
Cysteinyl leukotriene receptor 1
(Homo sapiens (Human)) | BDBM50084793
(4-Oxo-2-(1H-tetrazol-5-yl)-4H-chromene-8-carboxyli...)Show SMILES O=C(NCc1ccc(OCc2ccc3ccccc3n2)cc1)c1cccc2c1oc(cc2=O)-c1nnn[nH]1 Show InChI InChI=1S/C28H20N6O4/c35-24-14-25(27-31-33-34-32-27)38-26-21(24)5-3-6-22(26)28(36)29-15-17-8-12-20(13-9-17)37-16-19-11-10-18-4-1-2-7-23(18)30-19/h1-14H,15-16H2,(H,29,36)(H,31,32,33,34) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 86 | n/a | n/a | n/a | n/a | n/a | n/a |
Zhejiang University
Curated by ChEMBL
| Assay Description
Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before L... |
Bioorg Med Chem 18: 5519-27 (2010)
Article DOI: 10.1016/j.bmc.2010.06.047
BindingDB Entry DOI: 10.7270/Q26D5TZ0 |
More data for this
Ligand-Target Pair | |