Found 3 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
C-X-C chemokine receptor type 3
(Homo sapiens (Human)) | BDBM50349641
(CHEMBL1808999)Show SMILES O=C(Nc1ccccc1)N1C[C@@H](C=C2[C@H]1Cc1c[nH]c3cccc2c13)C(=O)N1CCC1 |r,c:13| Show InChI InChI=1S/C25H24N4O2/c30-24(28-10-5-11-28)17-12-20-19-8-4-9-21-23(19)16(14-26-21)13-22(20)29(15-17)25(31)27-18-6-2-1-3-7-18/h1-4,6-9,12,14,17,22,26H,5,10-11,13,15H2,(H,27,31)/t17-,22-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Antagonist activity at human CXCR3 expressed in mouse L1.2 cells assessed as inhibition of ITAC-induced calcium mobilization by FLIPR assay |
Bioorg Med Chem Lett 21: 4745-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.070 BindingDB Entry DOI: 10.7270/Q2VM4CN5 |
More data for this Ligand-Target Pair | |
C-X-C chemokine receptor type 3
(Mus musculus) | BDBM50349641
(CHEMBL1808999)Show SMILES O=C(Nc1ccccc1)N1C[C@@H](C=C2[C@H]1Cc1c[nH]c3cccc2c13)C(=O)N1CCC1 |r,c:13| Show InChI InChI=1S/C25H24N4O2/c30-24(28-10-5-11-28)17-12-20-19-8-4-9-21-23(19)16(14-26-21)13-22(20)29(15-17)25(31)27-18-6-2-1-3-7-18/h1-4,6-9,12,14,17,22,26H,5,10-11,13,15H2,(H,27,31)/t17-,22-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Antagonist activity at mouse CXCR3 expressed in mouse L1.2 cells assessed as inhibition of ITAC-induced calcium mobilization by FLIPR assay |
Bioorg Med Chem Lett 21: 4745-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.070 BindingDB Entry DOI: 10.7270/Q2VM4CN5 |
More data for this Ligand-Target Pair | |
C-X-C chemokine receptor type 3
(Homo sapiens (Human)) | BDBM50349641
(CHEMBL1808999)Show SMILES O=C(Nc1ccccc1)N1C[C@@H](C=C2[C@H]1Cc1c[nH]c3cccc2c13)C(=O)N1CCC1 |r,c:13| Show InChI InChI=1S/C25H24N4O2/c30-24(28-10-5-11-28)17-12-20-19-8-4-9-21-23(19)16(14-26-21)13-22(20)29(15-17)25(31)27-18-6-2-1-3-7-18/h1-4,6-9,12,14,17,22,26H,5,10-11,13,15H2,(H,27,31)/t17-,22-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 61 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Displacement of radiolabeled CXCL11 from human CXCR3 expressed in CHO cells by scintillation proximity assay |
Bioorg Med Chem Lett 21: 4745-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.070 BindingDB Entry DOI: 10.7270/Q2VM4CN5 |
More data for this Ligand-Target Pair | |