Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 359.4 BDBM50361430

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Perforin-1 (Homo sapiens (Human))	BDBM50361430 (CHEMBL1934394) Show SMILES O=C1NC(=S)S\C1=C\c1ccc(s1)-c1ccc2C(=O)OCc2c1 |w:8.8| Show InChI InChI=1S/C16H9NO3S3/c18-14-13(23-16(21)17-14)6-10-2-4-12(22-10)8-1-3-11-9(5-8)7-20-15(11)19/h1-6H,7H2,(H,17,18,21)/b13-6+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin-mediated lysis of Jurkat cells assessed as [51Cr] release preincubated with perforin for 30 mins followed by incub...				Bioorg Med Chem 20: 1319-36 (2012) Article DOI: 10.1016/j.bmc.2011.12.011 BindingDB Entry DOI: 10.7270/Q29C6XW9
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