Found 3 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50355506
(CHEMBL1910308)Show SMILES O[C@@]1(CCNC[C@@H]1C(=O)N(Cc1cn(Cc2ncco2)c2cccc(F)c12)C1CC1)c1ccc(F)c(F)c1 |r| Show InChI InChI=1S/C28H27F3N4O3/c29-21-7-4-18(12-23(21)31)28(37)8-9-32-13-20(28)27(36)35(19-5-6-19)15-17-14-34(16-25-33-10-11-38-25)24-3-1-2-22(30)26(17)24/h1-4,7,10-12,14,19-20,32,37H,5-6,8-9,13,15-16H2/t20-,28+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description Binding affinity to human ERG |
Bioorg Med Chem Lett 21: 3976-81 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.014 BindingDB Entry DOI: 10.7270/Q21N81HN |
More data for this Ligand-Target Pair | |
Renin
(Homo sapiens (Human)) | BDBM50355506
(CHEMBL1910308)Show SMILES O[C@@]1(CCNC[C@@H]1C(=O)N(Cc1cn(Cc2ncco2)c2cccc(F)c12)C1CC1)c1ccc(F)c(F)c1 |r| Show InChI InChI=1S/C28H27F3N4O3/c29-21-7-4-18(12-23(21)31)28(37)8-9-32-13-20(28)27(36)35(19-5-6-19)15-17-14-34(16-25-33-10-11-38-25)24-3-1-2-22(30)26(17)24/h1-4,7,10-12,14,19-20,32,37H,5-6,8-9,13,15-16H2/t20-,28+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.0600 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description Inhibition of human recombinant renin using DNP-Lys-His-Pro-Phe-His-Leu-Val-Ile-His-D,L-Amp as Q-FRET substrate after 3 hrs by fluorescence assay |
Bioorg Med Chem Lett 21: 3976-81 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.014 BindingDB Entry DOI: 10.7270/Q21N81HN |
More data for this Ligand-Target Pair | |
Renin
(Homo sapiens (Human)) | BDBM50355506
(CHEMBL1910308)Show SMILES O[C@@]1(CCNC[C@@H]1C(=O)N(Cc1cn(Cc2ncco2)c2cccc(F)c12)C1CC1)c1ccc(F)c(F)c1 |r| Show InChI InChI=1S/C28H27F3N4O3/c29-21-7-4-18(12-23(21)31)28(37)8-9-32-13-20(28)27(36)35(19-5-6-19)15-17-14-34(16-25-33-10-11-38-25)24-3-1-2-22(30)26(17)24/h1-4,7,10-12,14,19-20,32,37H,5-6,8-9,13,15-16H2/t20-,28+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.570 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description Inhibition of human recombinant renin in human plasma using QXL520-Lys-His-Pro-Phe-His-Leu-Val-Ile-His-Lys-(5-FAM) as Q-FRET substrate after 1 hr by ... |
Bioorg Med Chem Lett 21: 3976-81 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.014 BindingDB Entry DOI: 10.7270/Q21N81HN |
More data for this Ligand-Target Pair | |