Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Beta-2 adrenergic receptor
(Homo sapiens (Human)) | BDBM50419699
(CHEMBL1947156)Show SMILES O[C@@H](CNCCc1cccc(c1)-c1cccc(CNCc2ccccc2)c1)c1ccc(O)c2[nH]c(=O)sc12 |r| Show InChI InChI=1S/C31H31N3O3S/c35-27-13-12-26(30-29(27)34-31(37)38-30)28(36)20-32-15-14-21-8-4-10-24(16-21)25-11-5-9-23(17-25)19-33-18-22-6-2-1-3-7-22/h1-13,16-17,28,32-33,35-36H,14-15,18-20H2,(H,34,37)/t28-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Displacement of radiolabeled iodocyanopindolol from recombinant beta2 adrenoceptor |
Bioorg Med Chem Lett 22: 689-95 (2011)
Article DOI: 10.1016/j.bmcl.2011.10.049 BindingDB Entry DOI: 10.7270/Q2KW5H90 |
More data for this Ligand-Target Pair | |
Beta-2 adrenergic receptor
(Homo sapiens (Human)) | BDBM50419699
(CHEMBL1947156)Show SMILES O[C@@H](CNCCc1cccc(c1)-c1cccc(CNCc2ccccc2)c1)c1ccc(O)c2[nH]c(=O)sc12 |r| Show InChI InChI=1S/C31H31N3O3S/c35-27-13-12-26(30-29(27)34-31(37)38-30)28(36)20-32-15-14-21-8-4-10-24(16-21)25-11-5-9-23(17-25)19-33-18-22-6-2-1-3-7-22/h1-13,16-17,28,32-33,35-36H,14-15,18-20H2,(H,34,37)/t28-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 0.631 | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Agonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometry |
Bioorg Med Chem Lett 22: 689-95 (2011)
Article DOI: 10.1016/j.bmcl.2011.10.049 BindingDB Entry DOI: 10.7270/Q2KW5H90 |
More data for this Ligand-Target Pair | |